1. Anti-infection
  2. HIV Reverse Transcriptase
  3. 4'-Ethynyl-2'-deoxyadenosine

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA),是一种核苷逆转录酶 (RT) 抑制剂, 是一种抗病毒活性分子,对耐药HIV变异型具有较强的抑制作用,在MT-4细胞中,EC50 值为 98 nM。4'-Ethynyl-2'-deoxyadenosine 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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4'-Ethynyl-2'-deoxyadenosine Chemical Structure

4'-Ethynyl-2'-deoxyadenosine Chemical Structure

CAS No. : 306305-07-7

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生物活性

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

HIV-1

 

分子量

275.26

Formula

C12H13N5O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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4'-Ethynyl-2'-deoxyadenosine 相关分类

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