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  4. 5-Amino-2-methoxyphenol

5-Amino-2-methoxyphenol 是一种酚类区域异构体。5-Amino-2-methoxyphenol 在小鼠福尔马林试验中表现出剂量依赖性的镇痛作用，其第二相效应的机制依赖于 FAAH 和 TRPV1。5-Amino-2-methoxyphenol 可用于镇痛相关研究。

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5-Amino-2-methoxyphenol

5-Amino-2-methoxyphenol Chemical Structure

CAS No. : 1687-53-2

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规格 价格 是否有货 数量
1 g ￥194
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5 g ￥349
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10 g ￥527
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25 g ￥1046
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50 g ￥1666
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100 g ￥2674
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5-Amino-2-methoxyphenol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research[1].

体外研究
(In Vitro)

5-Amino-2-methoxyphenol (compound 2) 与 FAAH 结合的量更多，尽管其结合效率较低，且在 FAAH+/+ 小鼠脑匀浆中与 4-Aminopyridine (HY-B0604) 结合的量也较少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-Amino-2-methoxyphenol 相关抗体:
体内研究
(In Vivo)

5-Amino-2-methoxyphenol (25-100 mg/kg，腹腔注射，单次给药) 在小鼠福尔马林试验中呈剂量依赖性地产生镇痛作用，其第二时相效应的机制依赖于 FAAH 和 TRPV1[1]。
5-Amino-2-methoxyphenol (300 mg/kg，腹腔注射，单次给药) 未引起明显的肝损伤，血清 ALT 水平和 ALT/AST 比值均未见异常[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8 weeks old)[1]
Dosage: 25, 50, 75 and 100 mg/kg
Administration: i.p., single dose
Result: Produces dose-dependent antinociception in both phases of the formalin test.
Its antinociceptive effect was inhibited by FAAH inhibitor URB937 (HY-116477) and TRPV1 antagonist Capsazepine (HY-15640) during the second, but not the first , phase of the formalin test at 50 mg/kg dose.
Did not affect locomotor activity in mice at 75 mg/kg.
分子量

139.15

Formula

C7H9NO2
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

5-Amino-2-methoxyphenol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Amino-2-methoxyphenol1687-53-2OthersAntinociceptionmouse formalin testFAAHTRPV1antinociceptionInhibitorinhibitorinhibit

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