2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 5-DACTHF

5-DACTHF  (Synonyms: 543U76; 5,11-Methenyltetrahydrohomofolate)

目录号: HY-14526
产品使用指南 技术支持

5-DACTHF (543U76) 是嘌呤从头生物合成的抑制剂。5-DACTHF 是一种 GAR-TFase 和 AICAR-TFase 抑制剂 (IC50 分别为 3 和 94 μM) 。5-DACTHF 是一种有效的抗肿瘤剂。

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5-DACTHF

5-DACTHF Chemical Structure

CAS No. : 118252-44-1

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5-DACTHF 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-427 IC50
43 nM
Compound: 1
Antitumor activity on A-427 lung carcinoma cell lines
Antitumor activity on A-427 lung carcinoma cell lines
[PMID: 2299624]
CCRF-CEM IC50
0.198 μM
Compound: 5-DACTHF
Cytotoxicity against human lymphoblastic leukemic CCRF-CEM cell line was evaluated as the concentration required for 50% inhibition of the growth of the control value
Cytotoxicity against human lymphoblastic leukemic CCRF-CEM cell line was evaluated as the concentration required for 50% inhibition of the growth of the control value
[PMID: 1552503]
CCRF-CEM IC50
198 nM
Compound: 2
In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line
In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line
[PMID: 8027993]
CCRF-CEM IC50
47 nM
Compound: 1
Antitumor activity on CCRF-CEM T-cell acute lymphoblastic leukemia cell lines
Antitumor activity on CCRF-CEM T-cell acute lymphoblastic leukemia cell lines
[PMID: 2299624]
Detroit 98 IC50
0.11 μM
Compound: 1
Evaluated in vitro for ability to inhibit the Detroit 98 cell lines
Evaluated in vitro for ability to inhibit the Detroit 98 cell lines
[PMID: 2299624]
L929 IC50
0.088 μM
Compound: 1
Evaluated in vitro for ability to inhibit the L cell lines.
Evaluated in vitro for ability to inhibit the L cell lines.
[PMID: 2299624]
MCF7 ED50
0.037 μM
Compound: 5-DACTHF
Effective dose which is required to inhibit 50% of the cell growth of MCF-7 cells in culture.
Effective dose which is required to inhibit 50% of the cell growth of MCF-7 cells in culture.
[PMID: 1995883]
MCF7 IC50
0.037 μM
Compound: 1
In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
[PMID: 1573633]
MCF7 IC50
37 nM
Compound: 1
Antitumor activity on MCF-7 breast adenocarcinoma cell lines
Antitumor activity on MCF-7 breast adenocarcinoma cell lines
[PMID: 2299624]
MCF7 IC50
37 μM
Compound: 2
Ability to inhibit growth of MCF-7 human breast adenocarcinoma in vitro
Ability to inhibit growth of MCF-7 human breast adenocarcinoma in vitro
[PMID: 8027993]
MOLT-4 IC50
0.7 μM
Compound: 1
Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4
Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4
[PMID: 2299624]
MOLT-4 IC50
1.2 μM
Compound: 1
Compound was evaluated for inhibition of [3H]methotrexate uptake into MOLT-4 cells
Compound was evaluated for inhibition of [3H]methotrexate uptake into MOLT-4 cells
[PMID: 1573633]
MOLT-4 IC50
1.2 μM
Compound: 2
Ability to inhibit [3H]methotrexate transport into MOLT-4 cells in vitro
Ability to inhibit [3H]methotrexate transport into MOLT-4 cells in vitro
[PMID: 8027993]
MOLT-4 IC50
58 nM
Compound: 1
Antitumor activity on MOLT-4 T-cell acute lymphoblastic leukemia cell lines
Antitumor activity on MOLT-4 T-cell acute lymphoblastic leukemia cell lines
[PMID: 2299624]
MOLT-4 IC50
94 μM
Compound: 1
In vitro inhibitory activity against MOLT-4 T-cell leukemia cell AICAR transformylase
In vitro inhibitory activity against MOLT-4 T-cell leukemia cell AICAR transformylase
[PMID: 1573633]
MOLT-4 IC50
94 μM
Compound: 1
Inhibition activity against AICAR formyltransferase determined against MOLT-4
Inhibition activity against AICAR formyltransferase determined against MOLT-4
[PMID: 2299624]
MOLT-4 IC50
94 μM
Compound: 5-DACTHF
Inhibition of 5-aminoimidazole-4-carboxamide AICAR formyltransferase in MOLT-4 cells
Inhibition of 5-aminoimidazole-4-carboxamide AICAR formyltransferase in MOLT-4 cells
[PMID: 1995883]
SW480 IC50
50 nM
Compound: 1
Antitumor activity on SW 480 colon adenocarcinoma cell lines
Antitumor activity on SW 480 colon adenocarcinoma cell lines
[PMID: 2299624]
WIL2 IC50
> 100 μM
Compound: 5-DACTHF
Inhibition of dihydrofolate reductase (DHFR) in WIL2 cells
Inhibition of dihydrofolate reductase (DHFR) in WIL2 cells
[PMID: 1995883]
WiDr IC50
45 nM
Compound: 1
Antitumor activity on WiDr colon adenocarcinoma cell lines
Antitumor activity on WiDr colon adenocarcinoma cell lines
[PMID: 2299624]
分子量

432.43

Formula

C19H24N6O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-DACTHF 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-DACTHF118252-44-1543U76 5,11-MethenyltetrahydrohomofolateDNA/RNA Synthesispurine biosynthesisantitumorMCF-7MOLT-4 cellsInhibitorinhibitorinhibit

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