2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT2A inverse agonist-1

5-HT2A inverse agonist-1 是一种5-HT2A 受体反向激动剂，其 IC50 值为 5.5 nM。5-HT2A inverse agonist-1 对 hERG 的抑制作用极小。5-HT2A inverse agonist-1 可用于神经系统疾病的研究，如帕金森病。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

5-HT2A inverse agonist-1

5-HT2A inverse agonist-1 Chemical Structure

CAS No. : 3028943-38-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

5-HT2A inverse agonist-1 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-HT2A inverse agonist-1 is a 5-HT2A receptor inverse agonist with a IC50 of 5.5 nM. 5-HT2A inverse agonist-1 shows minimal hERG inhibition. 5-HT2A inverse agonist-1 can be used for the research of neurological disease, such as Parkinson’s disease[1].

IC50 & Target[1]

5-HT2A Receptor

5.5 nM (IC50)

体内研究
(In Vivo)

5-HT2A inverse agonist-1 (Compound P25a) (0.47-4.27 μmol/kg，灌胃) 可减轻 DOI 诱导的头部抽搐大鼠模型的头部抽搐症状[1]。
5-HT2A inverse agonist-1 (0.51-5.1 μmol/kg，灌胃) 能减少 MK801 (HY-15084B) 诱导的活动亢进大鼠模型的活动距离[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DOI-induced head twitches rats models[1]
Dosage: 0.47, 1.41, 4.27 μmol/kg
Administration: Orally gavage
Result: Reduced numbers of head twitches.
Animal Model: MK801-induced hyperactivity rats models[1]
Dosage: 0.51, 1.7 and 5.1 μmol/kg
Administration: Orally gavage
Result: Decreases activity distance.
分子量

472.45

Formula

C22H25F5N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-HT2A inverse agonist-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-HT2A inverse agonist-13028943-38-35-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2AhERGParkinson’s diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
5-HT2A inverse agonist-1
目录号：
HY-175822
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z