2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Keap1-Nrf2 Reactive Oxygen Species (ROS)
  4. 7-Deacetylgedunin

7-Deacetylgedunin 是 Keap1/Nrf2/HO-1的激活剂。7-Deacetylgedunin 减轻 LPS 诱导的小鼠死亡。7-Deacetylgedunin 抑制了 Keap1 表达和巨噬细胞增殖。7-Deacetylgedunin 对体内外炎症均有抑制作用。

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7-Deacetylgedunin

7-Deacetylgedunin Chemical Structure

CAS No. : 10314-90-6

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7-Deacetylgedunin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 20 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
AZ-521 cell line IC50
16.9 μM
Compound: 17
Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
HepG2 IC50
10.26 μM
Compound: 12
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
[PMID: 19908853]
HL-60 IC50
> 20 μM
Compound: 17
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
Huh-7 CC50
105 μM
Compound: 9
Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay
Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay
[PMID: 25330401]
Huh-7 EC50
12.5 μM
Compound: 9
Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay
Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay
[PMID: 25330401]
MCF7 IC50
28.96 μM
Compound: 2
Antiproliferative activity against human MCF7 cells after 72 hrs
Antiproliferative activity against human MCF7 cells after 72 hrs
[PMID: 18816111]
RAW264.7 IC50
< 10 μM
Compound: 7
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method
[PMID: 21733687]
RAW264.7 IC50
37.58 μM
Compound: 7
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 21733687]
RAW264.7 IC50
9.191 μM
Compound: B; DAG
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay
Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay
[PMID: 35427124]
SK-BR-3 IC50
12 μM
Compound: 17
Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
SK-BR-3 IC50
21.09 μM
Compound: 2
Antiproliferative activity against human SKBr3 cells after 72 hrs
Antiproliferative activity against human SKBr3 cells after 72 hrs
[PMID: 18816111]
分子量

440.53

Formula

C26H32O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Deacetylgedunin 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Deacetylgedunin10314-90-6Keap1-Nrf2Reactive Oxygen Species (ROS)Keap1/Nrf2/HO-1 ActivatorInflammatory responses7-DGDInhibitorinhibitorinhibit

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