1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. 7-Hydroxymethotrexate

7-Hydroxymethotrexate 

目录号: HY-130569
产品使用指南

7-Hydroxymethotrexate 是 Methotrexate (MTX; HY-14519) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂,可以抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸,并抑制 DNA 合成。

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7-Hydroxymethotrexate Chemical Structure

7-Hydroxymethotrexate Chemical Structure

CAS No. : 5939-37-7

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Description

7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

In Vitro

7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR is markedly lower (>100-fold) than for Methotrexate (MTX) [1].

In Vivo

7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg[1].

Animal Model: Male Wistar rats (270-440 g)[1]
Dosage: 4 mg/kg
Administration: IV
Result: Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg.
Molecular Weight

470.44

Formula

C₂₀H₂₂N₈O₆

CAS No.

5939-37-7

中文名称

7-羟基甲氨蝶呤

SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3NC2=O)C)C=C1)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

7-HydroxymethotrexateDrug MetaboliteMethotrexateMTXantimetaboliteantifolateenzymedihydrofolatereductasetetrahydrofolateDNAsynthesisInhibitorinhibitorinhibit

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7-Hydroxymethotrexate
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HY-130569
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