2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. HIF/HIF Prolyl-Hydroxylase VEGFR
  4. 7-Hydroxyneolamellarin A

7-Hydroxyneolamellarin A 是一种天然产物，可以从海绵 Dendrilla nigra 中提取。7-Hydroxyneolamellarin A 是一种有效的缺氧诱导因子 1α (HIF-1α) 抑制剂。7-Hydroxyneolamellarin A 减弱缺氧诱导因子-1α (HIF-1α) 蛋白的积累并抑制血管表皮生长因子 (VEGF) 的转录活性。7-Hydroxyneolamellarin A 可用于癌症的研究。

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7-Hydroxyneolamellarin A Chemical Structure

7-Hydroxyneolamellarin A Chemical Structure

CAS No. : 959662-26-1

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7-Hydroxyneolamellarin A 相关抗体

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查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].

体外研究
(In Vitro)

7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性[1]。
7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平[1]。
7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7-Hydroxyneolamellarin A 相关抗体:

Western Blot Analysis[1]

Cell Line: Hela cells, MCF-7 cells and 4T1 cells
Concentration: 0, 50, 100, and 150 μM
Incubation Time: 12 hours
Result: Decreased the HIF-1α protein levels in a dose-dependent manner.
体内研究
(In Vivo)

7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with 4T1 cells xenografts[1]
Dosage: 15 mg/kg
Administration: Intravenous injection; every 2 days for 16 days
Result: Inhibited tumor growth in vivo.
分子量

401.41

Formula

C24H19NO5
CAS 号
结构分类
初始来源

Dendrilla nigra
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Hydroxyneolamellarin A 相关分类

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Keywords:

7-Hydroxyneolamellarin A959662-26-1HIF/HIF Prolyl-HydroxylaseVEGFRHypoxia-inducible factorsHIFsHIF-PHVascular endothelial growth factor receptorsponge Dendrilla nigranatural producttumor angiogenesisproliferationmigrationinvasion.Inhibitorinhibitorinhibit

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