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C-Phycocyanin  (Synonyms: C-藻蓝蛋白; C-PC)

目录号: HY-D1025
COA 产品使用指南

C-phycocyanin (C-PC) 是一种蛋白质色素,也广泛用作人类的优良营养补充剂。

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C-Phycocyanin Chemical Structure

C-Phycocyanin Chemical Structure

CAS No. : 11016-15-2

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

C-phycocyanin (C-PC) is a protein pigment which is also widely used as an excellent nutrient supplement for human beings.

体外研究
(In Vitro)

对于组合实验,全反式维甲酸 (ATRA) 联合 C-Phycocyanin 处理细胞时,IC50 值低于ATRA 组。但在相同 IC50 下,C-phycocyanin 用量越多,ATRA 用量越少。结果表明,C-Phycocyanin 联合 ATRA可显著降低 CDK-4 mRNA 水平 (P<0.05)。C-Phycocyanin +ATRA 联合组的联合指数 (CI) 值为 0.852,小于 1,表明在 88 μg/L C-Phycocyanin +0.102 mM ATRA 的作用浓度下,具有协同作用。与对照组相比,C-Phycocyanin 或 ATRA 处理组的综合光密度 (IOD) 增加,差异有统计学意义 (P<0.05),联合组差异进一步扩大 (P<0.01)。C-Phycocyanin 组 caspase-3 的表达高于对照组,但与 ATRA 组相似,而联合组的表达量最大[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

与对照组相比,单独 C-Phycocyanin 或 ATRA 处理组的小鼠平均肿瘤重量显著降低,C-Phycocyanin +ATRA 协同组进一步降低。结果表明,单一的 C-Phycocyanin 可以增加小鼠的脾脏重量,而 ATRA 的作用恰恰相反。C-Phycocyanin 还可以促进小鼠免疫器官的生长,提高机体的免疫功能。C-Phycocyanin 与 ATRA 单独使用可显著抑制 Cyclin D1的表达,联合使用时抑制效果更明显[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号
性状

液体

颜色

Light blue to blue

中文名称

C-藻蓝蛋白;C-藻蓝素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

参考文献
Cell Assay
[1]

A549 cells are divided into four groups: (1) control group: the cells are not treated with any drug. (2) C-phycocyanin (C-PC) treated group: the cells are treated with C-phycocyanin alone. (3) All-trans retinoic acid (ATRA) treated group: the cells were treated with ATRA alone. (4) C-phycocyanin+ATRA combined group: the cells are treated simultaneously with C-phycocyanin and ATRA. For the combined treatment group, the combination index (CI) between two drugs is calculated. CI values of less than, equal to, and more than 1 indicate synergy, additivity, and antagonism, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

A total of 40 adult NU/NU mice (20 males and 20 females, 20 to 22 g) are used for the study. The mouse tumor models are set up by subcutaneous injection of 2×106 A549 cells near the armpit area. Fifteen days later, the mice are randomly divided into four groups: control group, All-trans retinoic acid (ATRA) treatment group which is treated with 0.2 mL ATRA (10 mM), C-phycocyanin treatment group which is given 0.2 mL C-phycocyanin (320 mg/mL), and C-phycocyanin+ATRA treatment group receiving 0.2 mL C-phycocyanin (320 mg/mL) and 0.2 mL ATRA (10 mM) at the same time. These agents are injected into the area of tumors and the duration of drug treatment is 10 days. Two days after drug withdrawal, the mice are executed, and then tumors and spleens are picked out[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

C-Phycocyanin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-D1025
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