1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Raxatrigine

Raxatrigine  (Synonyms: Vixotrigine; GSK-1014802; CNV1014802)

目录号: HY-12796 纯度: 99.85%
COA 产品使用指南

Raxatrigine (GSK-1014802) 是钠离子通道Nav1.7有效抑制剂。

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Raxatrigine Chemical Structure

Raxatrigine Chemical Structure

CAS No. : 934240-30-9

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货
1 mg ¥480
询问价格 & 货期

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Raxatrigine 的其他形式现货产品:

Other Forms of Raxatrigine:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

IC50 & Target

Nav1.7

 

体外研究
(In Vitro)

Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

314.35

Formula

C18H19FN2O2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 83 mg/mL (264.04 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1812 mL 15.9058 mL 31.8117 mL
5 mM 0.6362 mL 3.1812 mL 6.3623 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1812 mL 15.9058 mL 31.8117 mL 79.5292 mL
5 mM 0.6362 mL 3.1812 mL 6.3623 mL 15.9058 mL
10 mM 0.3181 mL 1.5906 mL 3.1812 mL 7.9529 mL
15 mM 0.2121 mL 1.0604 mL 2.1208 mL 5.3019 mL
20 mM 0.1591 mL 0.7953 mL 1.5906 mL 3.9765 mL
25 mM 0.1272 mL 0.6362 mL 1.2725 mL 3.1812 mL
30 mM 0.1060 mL 0.5302 mL 1.0604 mL 2.6510 mL
40 mM 0.0795 mL 0.3976 mL 0.7953 mL 1.9882 mL
50 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5906 mL
60 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3255 mL
80 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9941 mL
100 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7953 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Raxatrigine
目录号:
HY-12796
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