1. Neuronal Signaling
  2. Serotonin Transporter Dopamine Transporter
  3. Dasotraline hydrochloride

Dasotraline hydrochloride  (Synonyms: SEP-225289 hydrochloride)

目录号: HY-12850A 纯度: 99.74%
COA 产品使用指南

Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。

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Dasotraline hydrochloride Chemical Structure

Dasotraline hydrochloride Chemical Structure

CAS No. : 675126-08-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550
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5 mg ¥500
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10 mg ¥800
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50 mg ¥1800
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100 mg ¥2800
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Customer Review

Other Forms of Dasotraline hydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

IC50 & Target

IC50: 4 nM (dopamine), 6 nM (norepinephrine), 11 nM (serotonin)[1]

体内研究
(In Vivo)

Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

328.66

Formula

C16H16Cl3N

CAS 号
性状

固体

颜色

White to off-white

中文名称

达索曲林盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 31 mg/mL (94.32 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : 1.61 mg/mL (4.90 mM; 超声助溶 (<60°C))

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0427 mL 15.2133 mL 30.4266 mL
5 mM 0.6085 mL 3.0427 mL 6.0853 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Dasotraline hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.0427 mL 15.2133 mL 30.4266 mL 76.0665 mL
DMSO 5 mM 0.6085 mL 3.0427 mL 6.0853 mL 15.2133 mL
10 mM 0.3043 mL 1.5213 mL 3.0427 mL 7.6066 mL
15 mM 0.2028 mL 1.0142 mL 2.0284 mL 5.0711 mL
20 mM 0.1521 mL 0.7607 mL 1.5213 mL 3.8033 mL
25 mM 0.1217 mL 0.6085 mL 1.2171 mL 3.0427 mL
30 mM 0.1014 mL 0.5071 mL 1.0142 mL 2.5355 mL
40 mM 0.0761 mL 0.3803 mL 0.7607 mL 1.9017 mL
50 mM 0.0609 mL 0.3043 mL 0.6085 mL 1.5213 mL
60 mM 0.0507 mL 0.2536 mL 0.5071 mL 1.2678 mL
80 mM 0.0380 mL 0.1902 mL 0.3803 mL 0.9508 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Dasotraline hydrochloride
目录号:
HY-12850A
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