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Imexon  (Synonyms: 亚美克松; BM 06002)

目录号: HY-15385 纯度: 99.79%
COA 产品使用指南

摩尔计算器

Imexon (BM 06002) 是一种氮杂环丙烷类化合物，具有抗癌的功效。

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Imexon Chemical Structure

Imexon Chemical Structure

CAS No. : 59643-91-3

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规格 价格 是否有货 数量
1 mg ￥5300
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Imexon 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.

体外研究
(In Vitro)

Imexon (BM 06002) induces oxidative stress in the ER, activates an ER stress response. Imexon (BM 06002) does not significantly alter the levels of eIF2B5, however there is a dose-dependent increase in the phosphorylation of eIF2alpha, as well as an increase in the levels of GTP exchange protein eIF2B2 in MiaPaCa-2, Panc-1, and BxPC3 cells[1]. Imexon (BM 06002) induces single-stranded breaks in the human A375 melanoma cells but only significantly at the highest concentrations for each agent compared to controls. Imexon plus DTIC cytotoxicity is additive[2]. Imexon (BM 06002) show inhibitory activities against MiaPaCa-2, Panc-1 and BxPC3, with IC50s of 275.5 ± 54.2, 147.4 ± 4.7 and 355.7 ± 114.7 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Imexon 相关抗体:
体内研究
(In Vivo)

Imexon (BM 06002) in combination with DTIC results in an increase in the peak plasma imexon level in non-tumor-bearing mice. The combination of both drugs increases plasma imexon AUC by 22% (p=0.026). Imexon (BM 06002) (100 mg/kg/day, i.v.) treatment decreases the body weight of SCID mice bearing human A375 melanoma tumors, but there is no significant difference in tumor growth[2]. Imexon (BM 06002) (100 mg/kg) in combination with GEM shows synergistic inhibition of Panc-1 tumor growth in SCID mice.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

111.10

Formula

C4H5N3O
CAS 号
性状

固体

颜色

White to off-white

中文名称

亚美克松
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (562.56 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 12.5 mg/mL (112.51 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 9.0009 mL 45.0045 mL 90.0090 mL
5 mM 1.8002 mL 9.0009 mL 18.0018 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.79%

COA (174 KB) HNMR (227 KB) RP-HPLC (89 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Cell survival for the siRNA screening experiments are calculated by the conversion of resazurin to resorufin by metabolically active cells resulting in a fluorescent product. Confirmatory growth inhibition assays with eIF2b silencing are done using the methyl-thiazolyl-diphenyl-tetrazolium bromide (MTT) assay. Cell growth inhibition data are expressed as percent survival, compared to untreated cells. The IC50 is defined as the drug concentration required to produce 50% growth inhibition.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

The effect of the combination on tumor growth in vivo is evaluated in 25-30 g male SCID mice (n=8/group). Mice receive 5×106 A375 cells subcutaneously and are pair matched on day 30, when the average tumor burden is approximately 100 mm3. Treatment begins the following day, as follows: (i) saline vehicle control; (ii) 80 mg/kg/day DTIC; (iii) 100 mg/kg/day imexon; (iv) a combination of both drugs at the same doses. Drugs are administered (i.p.) for nine consecutive days and imexon is administered 15 min before DTIC when combined. Measurement of tumor burden and body weights are made every 3-4 days. Tumor burden (mm3) is calculated as (length × width2)/2.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Imexon 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 9.0009 mL 45.0045 mL 90.0090 mL 225.0225 mL
5 mM 1.8002 mL 9.0009 mL 18.0018 mL 45.0045 mL
10 mM 0.9001 mL 4.5005 mL 9.0009 mL 22.5023 mL
15 mM 0.6001 mL 3.0003 mL 6.0006 mL 15.0015 mL
20 mM 0.4500 mL 2.2502 mL 4.5005 mL 11.2511 mL
25 mM 0.3600 mL 1.8002 mL 3.6004 mL 9.0009 mL
30 mM 0.3000 mL 1.5002 mL 3.0003 mL 7.5008 mL
40 mM 0.2250 mL 1.1251 mL 2.2502 mL 5.6256 mL
50 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5005 mL
60 mM 0.1500 mL 0.7501 mL 1.5002 mL 3.7504 mL
80 mM 0.1125 mL 0.5626 mL 1.1251 mL 2.8128 mL
100 mM 0.0900 mL 0.4500 mL 0.9001 mL 2.2502 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imexon59643-91-3BM 06002亚美克松BM06002BM-06002OthersInhibitorinhibitorinhibit

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