1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Pradefovir mesylate

Pradefovir mesylate  (Synonyms: Remofovir mesylate)

目录号: HY-112690A 纯度: 99.53%
COA 产品使用指南

Pradefovir mesylate 是肝脏 CYP3A4 的良好底物。Pradefovir 在人肝微粒体中转化为 9-[2-(磷酸甲氧基)乙基]腺嘌呤 (PMEA),Km 为 60 μM。

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Pradefovir mesylate Chemical Structure

Pradefovir mesylate Chemical Structure

CAS No. : 625095-61-6

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ¥6291
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1 mg ¥2095
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5 mg ¥5500
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10 mg ¥8500
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.

IC50 & Target

CYP3

 

体外研究
(In Vitro)

Pradefovir is a cyclodiester prodrug of PMEA. It is one of the HepDirect prodrugs, which are designed to be efficiently and specifically activated through an oxidative reaction catalyzed by CYP3A4, which is located mainly in the liver. Pradefovir is converted to PMEA in human liver microsomes with a Km of 60 μM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 L/min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Daily oral dosing of Pradefovir (300 mg/kg) to rats for 8 days does not affect body weight; liver weight; liver weight-body weight ratio; liver microsomal protein content; total CYP content; enzyme activities for CYP1A, CYP2B, and CYP3A; and apoprotein contents for CYP1A1, CYP2B1/2, CYP3A1/2, and CYP4A1/3, indicating that Pradefovir is not a CYP inducer in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

519.90

Formula

C18H23ClN5O7PS

CAS 号
性状

固体

颜色

White to off-white

中文名称

甲磺酸帕拉德福韦;甲磺酸瑞莫夫韦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (192.34 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9234 mL 9.6172 mL 19.2345 mL
5 mM 0.3847 mL 1.9234 mL 3.8469 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (192.34 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.89%

参考文献
Animal Administration
[1]

Rats[1]
Five rats receive Pradefovir (300 mg/kg/day) orally for 8 days. At 24 h after administration of the last dose, the rats are killed and liver samples are collected. Body weight, liver weight, liver protein content, and liver microsomal P450 contents are determined. The apoprotein levels for CYP1A1, CYP2B1/2B2, CYP3A1/3A2, and CYP4A1/4A3 and the enzyme activities for CYP1A, CYP2B, and CYP3A are also determined by Western blot and LC analysis, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Pradefovir mesylate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9234 mL 9.6172 mL 19.2345 mL 48.0862 mL
5 mM 0.3847 mL 1.9234 mL 3.8469 mL 9.6172 mL
10 mM 0.1923 mL 0.9617 mL 1.9234 mL 4.8086 mL
15 mM 0.1282 mL 0.6411 mL 1.2823 mL 3.2057 mL
20 mM 0.0962 mL 0.4809 mL 0.9617 mL 2.4043 mL
25 mM 0.0769 mL 0.3847 mL 0.7694 mL 1.9234 mL
30 mM 0.0641 mL 0.3206 mL 0.6411 mL 1.6029 mL
40 mM 0.0481 mL 0.2404 mL 0.4809 mL 1.2022 mL
50 mM 0.0385 mL 0.1923 mL 0.3847 mL 0.9617 mL
60 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8014 mL
80 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6011 mL
100 mM 0.0192 mL 0.0962 mL 0.1923 mL 0.4809 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Pradefovir mesylate
目录号:
HY-112690A
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