2. Anti-infection
  3. HSV
  4. Tromantadine

Tromantadine  (Synonyms: 曲金刚胺)

目录号: HY-U00124
COA 产品使用指南

摩尔计算器

Tromantadine，Amantadine 衍生物，具有抗疱疹活性，可抑制单纯疱疹病毒1型 (HSV-1) 和 HSV-2 的复制。

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Tromantadine Chemical Structure

Tromantadine Chemical Structure

CAS No. : 53783-83-8

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Tromantadine 的其他形式现货产品:

Other Forms of Tromantadine:

Tromantadine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].

IC50 & Target[1]

HSV-1

 

HSV-2

 

体外研究
(In Vitro)

Tromantadine inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and virus replication with limited toxicity to the cells. Vero and HEp-2 cells tolerate up to 2 mg of Tromantadine per 2x106 cells for 24-, 48-, or 96-h incubation periods with little change in cell morphology. Treatment of the cells with 10 to 50 μg of Tromantadine reduces herpes simplex virus-induced cytopathic effect. Treatment with 100 to 500 μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500 μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection. Virion synthesis and viral polypeptide synthesis are inhibited by addition of Tromantadine at the time of infection or 4 h postinfection[1]. Tromantadine raises the bilayer to hexagonal phase transition temperature of synthetic phosphatidylethanolamines and is less disruptive to phospholipid packing. Tromantadine acts similar to cyclosporin A, previously demonstrated to inhibit viral-induced cell-cell fusion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tromantadine 相关抗体:
分子量

280.41

Formula

C16H28N2O2
CAS 号
性状

油状物

颜色

Colorless to light yellow

中文名称

曲金刚胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
Cell Assay
[1]

Confluent monolayers of Vero (2.4x106 per plate) or HEp-2 (1.6x106 per plate) cells are treated with various amounts of Tromantadine 15 min before and then throughout the infection and incubation. The dose of Tromantadine applied, rather than the concentration, is varied since, as for amantadine, the cells concentrate the compound from the medium. For most assays, cells are infected with 6x108 PFU of HSV-1 in 0.5 mL for 1 h at 37°C, and the virus solution is then aspirated off the monolayer and replaced with 2 mL of maintenance medium containing the same amount of the compound. The antiviral activity of the compounds is determined as a reduction in both virally induced cytopathic effect (CPE) and production of extracellular infectious virus 24, 48, and % h postinfection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Tromantadine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tromantadine53783-83-8曲金刚胺HSVHerpes simplex virusHSV-1HSV-2replicationvirusantiherpeticinfectioncytopathictoxicityInhibitorinhibitorinhibit

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