1. GPCR/G Protein Immunology/Inflammation Autophagy
  2. CXCR Autophagy
  3. UNBS5162

UNBS5162 是一种广谱的趋化因子配体 CXCL 拮抗剂,具有抗肿瘤活性。

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UNBS5162 Chemical Structure

UNBS5162 Chemical Structure

CAS No. : 956590-23-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1650
In-stock
5 mg ¥937
In-stock
10 mg ¥1500
In-stock
50 mg ¥4500
In-stock
100 mg ¥7500
In-stock
200 mg   询价  
500 mg   询价  

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Top Publications Citing Use of Products

    UNBS5162 purchased from MCE. Usage Cited in: Thorac Cancer. 2018 Jan;9(1):105-111.  [Abstract]

    Apoptosis is induced by UNBS5162 treatment in human A549 non-small cell lung cancer (NSCLC) cells. Western blot analysis of apoptosis protein expression in human A549 NSCLC cells.

    UNBS5162 purchased from MCE. Usage Cited in: Exp Ther Med. 2018 Nov;16(5):3921-3928.  [Abstract]

    The effect of UNBS5162 on MDA-MB-231 cell apoptosis detected using western blot. Western blot assay is utilized to determine BCL-2, BAX and active caspase-3 protein expression levels in MDA MB 231 cells extracts.

    UNBS5162 purchased from MCE. Usage Cited in: Med Sci (Paris). 2018 Oct;34 Focus issue F1:99-104.  [Abstract]

    The expression levels of Bcl-2, Bax and active caspase-3 proteins are measured using Western-blot analyses after incubation with UNBS5162 or DMSO for 24 h.

    UNBS5162 purchased from MCE. Usage Cited in: Med Sci (Paris). 2018 Oct;34 Focus issue F1:99-104.  [Abstract]

    Western-blot analysis of proteins involved in the PI3K/Akt signaling pathway in HCT116 cells cultured in presence of UNBS5162 or DMSO (NC).

    UNBS5162 purchased from MCE. Usage Cited in: Onco Targets Ther. 2017 Nov 6;10:5303-5309.  [Abstract]

    UNBS5162 inhibits proliferation of human retinoblastoma cells through the Akt–mTOR pathway. Following Western blot, expression of Akt-pathway and key proliferation-related genes- those for p-Akt, p-mTOR, p70, and cyclin D1-is found to be downregulated significantly in the UNBS5162-treated group compared with the negative-control (NC) group in Y79 cells.

    UNBS5162 purchased from MCE. Usage Cited in: Onco Targets Ther. 2017 Nov 6;10:5303-5309.  [Abstract]

    UNBS5162 inhibits proliferation of human retinoblastoma cells through the Akt–mTOR pathway. Following Western blot, expression of Akt-pathway and key proliferation-related genes- those for p-Akt, p-mTOR, p70, and cyclin D1-is found to be downregulated significantly in the UNBS5162-treated group compared with the negative-control (NC) group in WERIRb1 cells.
    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.

    IC50 & Target[1]

    CXCL

     

    体外研究
    (In Vitro)

    UNBS5162 is a pan-antagonist of CXCL chemokine expression and exhibits weak antiproliferative activity against human cancer cell lines with mean IC50 of 17.9 µM. UNBS5162 markedly impairs PC-3 tumor cell growth kinetics, without inducing senescence, whereas the reverse feature is observed with respect to DU-145 cells[1]. UNBS5162 is cytotoxic to a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7), with IC50s of 0.5-5 µM. UNBS5162 also markedly increases the levels of expression of LC3-I and LC3-II in human cancer cells. UNBS5162 displays no anti-topoisomerase II activity. Moreover, UNBS5162 induces cancer cell death through lysosomal membrane permeabilization (LMP) in PC3 prostate cancer cells but not in U373 glioblastoma cells, with this LMP process occurring as an UNBS5162-induced decrease in Hsp70 expression[2]. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. UNBS5162 downregulates the protein expression of proteins associated with the PI3K/AKT signaling pathway, including the levels of phosphorylated (p)-AKT, p-mechanistic target of rapamycin kinase, ribosomal protein S6 kinase β1 and cyclin D1[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    UNBS5162 (20 mg/kg, i.v.) increases the therapeutic benefits of taxol in vivo in the orthotopic human PC-3 prostate cancer model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    326.35

    Formula

    C17H18N4O3

    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 21.5 mg/mL (65.88 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.0642 mL 15.3210 mL 30.6419 mL
    5 mM 0.6128 mL 3.0642 mL 6.1284 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献
    Animal Administration
    [1]

    Mice[1]
    Orthotopic xenografts are obtained by injecting 2.5 × 106 human PC-3 or DU-145 cells into the prostate of 6-week-old male nu/nu mice (n = 9 animals per treatment group). All grafts are performed under anesthesia [saline/Rompun/Imalgene; 5:1:1 by volume]. The end point in these orthotopic experiments is the survival period of the tumor-bearing mice after the administration of UNBS3157, UNBS5162, or reference anticancer agents (taxol, mitoxantrone, and amonafide). However, for ethical reasons, animals are killed when 20% of body weight have been lost compared to that determined at the time of tumor grafting. All animals are weighed three times a week. Autopsies and histologic diagnoses are performed on each mouse to confirm the presence of tumor development; 100% is achieved. In the case of UNBS5162 experiments in the PC-3 model, after the sacrifice of animals, tumors are removed from both drug-treated [10 mg/kg, intravenous (i.v.)] and vehicle-treated mice, fixed in buffered formalin, embedded in paraffin, and 5-µm-thick sections taken. These histologic slides are then stained with hematoxylin and eosin for blood vessel counts[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0642 mL 15.3210 mL 30.6419 mL 76.6049 mL
    5 mM 0.6128 mL 3.0642 mL 6.1284 mL 15.3210 mL
    10 mM 0.3064 mL 1.5321 mL 3.0642 mL 7.6605 mL
    15 mM 0.2043 mL 1.0214 mL 2.0428 mL 5.1070 mL
    20 mM 0.1532 mL 0.7660 mL 1.5321 mL 3.8302 mL
    25 mM 0.1226 mL 0.6128 mL 1.2257 mL 3.0642 mL
    30 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5535 mL
    40 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9151 mL
    50 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5321 mL
    60 mM 0.0511 mL 0.2553 mL 0.5107 mL 1.2767 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    UNBS5162
    目录号:
    HY-16509
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