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    Apoptosis
  2. LPL Receptor
    Apoptosis
  3. W146

W146 

目录号: HY-101395
产品使用指南

W146 是 1-磷酸-鞘氨醇受体亚型 1 (S1PR1) 的选择性拮抗剂, EC50 值为 398 nM。

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W146 Chemical Structure

W146 Chemical Structure

CAS No. : 909725-61-7

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规格 是否有货
500 μg
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  • 生物活性

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  • 参考文献

生物活性

W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

IC50 & Target

EC50: 398 nM (S1PR1)[1].

体外研究
(In Vitro)

W146 is a S1PR1 antagonist with a Ki of ~70-80 nM[1].
W146 pretreatment significantly increases activated cleaved caspase-3 levels. The reduced EPCs apoptosis which induced by S1P is completely abolished after treatment with W146[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Endothelial progenitor cells (EPCs).
Concentration: 10 μM.
Incubation Time: 30 min before the addition of S1P.
Result: Increases activated cleaved caspase-3 levels.
体内研究
(In Vivo)

W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (4-6-week-old)[3]
.
Dosage: 5 mg/kg.
Administration: IP, 1 hour prior to AMD3100 (ADM) administration.
Result: Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration.
分子量

342.37

Formula

C16H27N2O4P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

纯度: ≥99.0%

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× = ×
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HY-101395
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