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  3. XCT790

XCT790 

目录号: HY-10426 纯度: 98.08%
产品使用指南

XCT-790 是 ERRα 的有效选择性反向激动剂,IC50 值为 0.37 μM。XCT-790 在化疗过程中诱导癌细胞死亡。XCT-790 对 ERRγ 和雌激素受体 ERα 和 ERβ 无活性。

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XCT790 Chemical Structure

XCT790 Chemical Structure

CAS No. : 725247-18-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1207
In-stock
10 mg ¥1097
In-stock
50 mg ¥4259
In-stock
100 mg   询价  
200 mg   询价  

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Top Publications Citing Use of Products

    XCT790 purchased from MCE. Usage Cited in: Oncogene. 2016 Sep 22;35(38):5033-42.

    Inhibition of the ERRα-dependent mitochondrial activity by XCT-790 is found to drastically inhibit decreased cell density and increase cell death induced by PLA2R1.

    XCT790 purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Sep 5;37(1):218.

    The proliferation proteins cMyc and cyclin D1 are identified and confirmed by Western blot analysis after the colon cancer cells are treated with the indicated concentrations of XCT790 or DMSO for 48 h.

    查看 Estrogen Receptor/ERR 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].

    IC50 & Target[1][2]

    ERRα

    0.37 μM (IC50)

    体外研究
    (In Vitro)

    XCT-790 (0-40 μM; 48 hours and 72 hours) reduces the viability of MES-SA, MES-SA/DX5, and HepG2 cells in a dose-dependent manner[1].
    XCT-790 (10 μM; 24 hours and 48 hours) reduces the protein levels of ERRα in HepG2 and R-HepG2 cell lines after 24 hours and maintains these reduced levels after 48 hours[1].
    XCT-790 (10 μM; 48 hours) induces apoptosis in the two cell lines with HepG2 being more sensitive compared to R-HepG2[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MES-SA, MES-SA/DX5, HepG2 and R-HepG2 cells
    Concentration: 0 μM, 5 μM, 10 μM, 20 μM, and 40 μM
    Incubation Time: 48 hours and 72 hours
    Result: The cells proliferation were decreased in a dose-dependent fashion.

    Western Blot Analysis[1]

    Cell Line: HepG2 and R-HepG2 cells
    Concentration: 10 μM
    Incubation Time: 24 hours and 48 hours
    Result: Reduced the protein levels of ERRα.

    Apoptosis Analysis[1]

    Cell Line: HepG2 and R-HepG2 cells
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Induced apoptosis in HepG2 and R-HepG2 cells.
    体内研究
    (In Vivo)

    XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/c mice (4 weeks of age) with HEC-1A xenograft[3]
    Dosage: 4 mg/kg
    Administration: Intravenous injection; every three days; for 3 weeks
    Result: Suppressed endometrial cancer growth and angiogenesis, and induced apoptosis.
    分子量

    596.42

    Formula

    C23H13F9N4O3S

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 16.67 mg/mL (27.95 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.6767 mL 8.3834 mL 16.7667 mL
    5 mM 0.3353 mL 1.6767 mL 3.3533 mL
    10 mM 0.1677 mL 0.8383 mL 1.6767 mL
    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 1.67 mg/mL (2.80 mM); Suspended solution; Need ultrasonic

      此方案可获得 1.67 mg/mL (2.80 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例,取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
    *以上所有助溶剂都可在 MCE 网站选购。
    参考文献

    纯度: 98.08%

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2

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    产品名称:
    XCT790
    目录号:
    HY-10426
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