2. GPCR/G Protein
  3. RXFP Receptor
  4. A13:B7-24-GG

A13:B7-24-GG，一种经过工程改造的胰岛素样肽 5 (INSL5) 类似物，是一种具有选择性的 RXFP4 激动剂，其 Ki 值为 2.29 nM。A13:B7-24-GG 对 RXFP3 的结合亲和力极低 (Ki = 602.56 nM)，对 cAMP 的抑制效力 (EC50) 为 1.17 nM。A13:B7-24-GG 激活 RXFP4 导致 β-Arrestin2 招募，EC50 为 22.39 nM。A13:B7-24-GG 可用于研究慢性便秘。

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A13:B7-24-GG

A13:B7-24-GG Chemical Structure

CAS No. : 3057097-31-8

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A13:B7-24-GG 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation[1].

分子量

3500.03

Formula

C149H236N40O47S5
CAS 号
Sequence

Chain1:Cys-Thr-Asp-Gly-Ala-Ser-Met-Lys-Asp-Leu-Ser-Ala-Leu-Cys Chain2:Cys-Gly-Leu-Glu-Tyr-Ile-Arg-Thr-Val-Ile-Tyr-Ile-Cys-Gly-Gly-Ser-Arg-Trp (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
Sequence Shortening

CTDGASMKDLSALC CGLEYIRTVIYICGGSRW (Disulfidebridge:Chain 1 Cys1-Chain 2 Cys1, Chain 1 Cys14-Chain 2 Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A13:B7-24-GG 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

A13:B7-24-GG3057097-31-8RXFP ReceptorRelaxin family peptideINSL5RXFP4peptide engineeringglycine substitutionreceptor selectivityagonist potencyInhibitorinhibitorinhibit

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