1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. ABT-866

ABT-866 是一种 α1A-肾上腺素受体激动剂和 α1B- 和 α1D-肾上腺素受体拮抗剂。ABT-866 对兔尿道 α1AEC50 为 0.60 μM。ABT-866 对大鼠脾脏 α1BpA2 为 5.4。ABT-866 对大鼠主动脉 α1DpA2 为 6.2。ABT-866 在压力性尿失禁模型中展现出较好的尿道选择性和更低的心血管副作用。ABT-866 可用于压力性尿失禁等的研究。

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ABT-866

ABT-866 Chemical Structure

CAS No. : 258526-74-8

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生物活性

ABT-866 is an α1A-adrenoceptor agonist and an antagonist at the α1B- and α1D-adrenoceptor subtypes. ABT-866 has an EC50 of 0.60 μM for the α1A in the rabbit urethra. ABT-866 has a pA2 value of 5.4 for the α1B in the rat spleen. ABT-866 has a pA2 value of 6.2 for the α1D in the rat aorta. ABT-866 exhibits good urethral selectivity and lower cardiovascular side effects in stress urinary incontinence models. ABT-866 can be used for research on conditions such as stress urinary incontinence[1][2].

分子量

265.33

Formula

C12H15N3O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ABT-866
目录号:
HY-119262
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