2. Apoptosis MAPK/ERK Pathway Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis JNK TNF Receptor p38 MAPK Reactive Oxygen Species (ROS) NF-κB Cytochrome P450 Interleukin Related COX SOD Heme Oxygenase (HO)
  4. Aflatoxin G1

Aflatoxin G1  (Synonyms: 黄曲霉毒素G1)

目录号: HY-N6697 纯度: 99.67%
COA 产品使用指南 技术支持

Aflatoxin G1 是一种具有口服活性的黄曲霉毒素，它可在 Aspergillus flavus 和 Aspergillus parasiticus 等霉菌中发现。 Aflatoxin G1 是大米，辣椒和其他粮食作物中发现的具有致毒和致癌性的霉菌毒素。Aflatoxin G1 可通过 MAPK 信号通路引起肺泡 II 型细胞的 DNA 损伤和细胞凋亡 (apoptosis)。Aflatoxin G1 上调 TNF-α，引发与肿瘤前期诱发有关的慢性肺部炎症。

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Aflatoxin G1

Aflatoxin G1 Chemical Structure

CAS No. : 1165-39-5

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Customer Review

Other Forms of Aflatoxin G1:

Aflatoxin G1 相关抗体

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JNK1 JNK2 JNK3 JNK

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aflatoxin G1 is an orally active aflatoxin found in the molds Aspergillus flavus and Aspergillus parasiticus. Aflatoxin G1 is a toxic and carcinogenic mycotoxin found in rice, pepper, and other food crops. Aflatoxin G1 induces DNA damage and apoptosis in alveolar type II cells via the MAPK signaling pathway. Aflatoxin G1 upregulates TNF-α, triggering chronic lung inflammation associated with preneoplastic induction[1][2][3].

体外研究
(In Vitro)

Aflatoxin G1 (0.5-10 μg/mL, 24 h) 在 A549 细胞中，通过增加 ROS 生成来诱导氧化应激，氧化性 DNA 损伤和细胞凋亡[1]。
Aflatoxin G1 (4 μg/mL, 预处理 0.5 h, 再处理 24 h) 在 SP600125 (HY-12041), SB203580 (HY-10256) 诱导的 A549 细胞中，说明其通过 JNK 和 p38 MAPK 信号通路诱导细胞凋亡[1]。
Aflatoxin G1 (4 μg/mL, 24 h) 在小鼠肺泡 II (AT-II) 和 A549 细胞中，协同 TNF-α 通过 NF-κB 通路进一步上调 CYP2A13，加剧氧化性 DNA 损伤和细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aflatoxin G1 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 2, 4, 10 μg/mL
Incubation Time: 24 h
Result: Led to upregulation of γ-H2AX protein expression in A549 cells.
Showed up-regulation of Fas, FasL, caspase-8, and Bax, down-regulation of Bcl-2, and activation of caspase-3 in A549 cells.

Western Blot Analysis[2]

Cell Line: Mouse AT-II cells and A549 cells
Concentration: 4 μg/mL, TNF-α (20 μg/ml) treatment
Incubation Time: 24 h
Result: Synergized with TNF-α to significantly enhance the expression of γ-H2AX, p-ATM and p-chk2 in A549 cells.
Synergistically with TNF-α significantly enhanced the expression of CYP2A13.
体内研究
(In Vivo)

Aflatoxin G1 (100 μg/kg，p.o.，每周 3 次，持续 3 个月) 在 Balb/c 小鼠中，通过CYP2A13的上调，导致 DNA 损伤，进而引发肺部炎症[2]。
Aflatoxin G1 (100 μg/kg，p.o.，每周 3 次，持续 6 个月) 在 Balb/c 小鼠中，可诱导肺泡隔发生慢性肺部炎症，从而显著促进氧化应激、细胞增殖和血管生成，并增强肺泡上皮中 COX-2 的表达，从而提供促肿瘤微环境[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (female 18-20 g)[2]
Dosage: 100 μg/kg
Administration: p.o., 3 times a week for 3 months
Result: Showed an increase in the number of γ-H2AX and 8-OHdG positive cells in inflamed lung tissue.
Showed elevated levels of CYP1A2, 2A6, and 2A13 proteins in inflamed lung tissue.
Animal Model: Balb/c nude mice (female 18-20 g)[2]
Dosage: 100 μg/kg
Administration: p.o., 3 times a week for 6 months
Result: Showed an increase in the number of γ-H2AX and 8-OHdG positive cells in inflamed lung tissue.
Showed elevated levels of CYP1A2, 2A6, and 2A13 proteins in inflamed lung tissue.
Increased expression of TNF-α, IL-1β, IL-6, MCP-1/CCL-2, MIP-2/CXCL-2, and CXCL-1.
Enhanced the expression of SOD-2 and HO-1 in chronic lung inflammation.
Enhanced alveolar epithelial cell proliferation and angiogenesis in chronic lung inflammation.
Increased COX-2 expression in alveolar epithelial cells in chronic inflammation.
分子量

328.27

Formula

C17H12O7
CAS 号
性状

固体

颜色

White to off-white

中文名称

黄曲霉毒素G1
结构分类
初始来源

Aspergillus flavus and Aspergillus parasiticus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (30.46 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0463 mL 15.2314 mL 30.4627 mL
5 mM 0.6093 mL 3.0463 mL 6.0925 mL
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纯度 & 产品资料

纯度: 99.67%

COA (295 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Aflatoxin G1 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0463 mL 15.2314 mL 30.4627 mL 76.1568 mL
5 mM 0.6093 mL 3.0463 mL 6.0925 mL 15.2314 mL
10 mM 0.3046 mL 1.5231 mL 3.0463 mL 7.6157 mL
15 mM 0.2031 mL 1.0154 mL 2.0308 mL 5.0771 mL
20 mM 0.1523 mL 0.7616 mL 1.5231 mL 3.8078 mL
25 mM 0.1219 mL 0.6093 mL 1.2185 mL 3.0463 mL
30 mM 0.1015 mL 0.5077 mL 1.0154 mL 2.5386 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aflatoxin G11165-39-5黄曲霉毒素G1Aflatoxin G 1Aflatoxin G-1ApoptosisJNKTNF Receptorp38 MAPKReactive Oxygen Species (ROS)NF-κBCytochrome P450Interleukin RelatedCOXSODHeme Oxygenase (HO)c-Jun N-terminal kinaseTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBCYPsILCyclooxygenaseSuperoxide DismutaseHeme OxygenaseMoldLung cancerBalb/c miceAT-II cellsInhibitorinhibitorinhibit

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