1. GPCR/G Protein
  2. Free Fatty Acid Receptor
  3. AM-5262

AM-5262 是一种 GPR40 完全激动剂,EC50 值为 0.081 μM。 AM-5262 可用于 II 型糖尿病的研究。

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AM-5262 Chemical Structure

AM-5262 Chemical Structure

CAS No. : 1222088-90-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-5262 is a GPR40 full agonist with an EC50 value of 0.081 μM. AM-5262 can be used for the research of type II diabetes[1].

IC50 & Target

EC50: 0.081 μM (GPR40)[1]

体外研究
(In Vitro)

AM-5262 对 GPR40 具有活性, EC50 值为 0.081 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AM-5262 (26) (i.v., 0.5 mg/kg; oral, 2 mg/kg) 改善大鼠药代动力学特征和一般选择性特征[1]
AM-5262(0-100 μM)增强葡萄糖刺激的胰岛素分泌(小鼠和人类胰岛)并改善体内葡萄糖稳态(HF/STZ 小鼠的 OGTT)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

514.63

Formula

C33H35FO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
AM-5262
目录号:
HY-16619
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