2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-2 Antibody (S4B6-1)

Anti-Mouse IL-2 Antibody (S4B6-1) 

目录号: HY-P990796
技术支持

Anti-Mouse IL-2 Antibody (S4B6-1) 是一种抗小鼠 IL-2 IgG2a 单克隆抗体。Anti-Mouse IL-2 Antibody (S4B6-1) 可以减少 CD4+ T 细胞并增加 Tregs。Anti-Mouse IL-2 Antibody (S4B6-1) 可诱导 Th17 细胞分化。Anti-Mouse IL-2 Antibody (S4B6-1) 可用于研究癌症如黑色素瘤。Anti-Mouse IL-2 Antibody (S4B6-1) 的同型对照为 Rat IgG2a kappa, Isotype Control (HY-P990679)。

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Anti-Mouse IL-2 Antibody (S4B6-1)

Anti-Mouse IL-2 Antibody (S4B6-1) Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse IL-2 Antibody (S4B6-1) 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-2 Antibody (S4B6-1) is an anti-mouse IL-2 IgG2a monoclonal antibody. Anti-Mouse IL-2 Antibody (S4B6-1) can reduce CD4+ T cells and increase Tregs. Anti-Mouse IL-2 Antibody (S4B6-1) can induce Th17 cell differentiation. Anti-Mouse IL-2 Antibody (S4B6-1) can be used for research on cancer such as melanoma. The recommend isotype control of Anti-Mouse IL-2 Antibody (S4B6-1): Rat IgG2a kappa, Isotype Control (HY-P990679)[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2][3]

IL-2

 

体外研究
(In Vitro)

Anti-Mouse IL-2 Antibody (S4B6-1) (10 μg/mL，72 小时) 可诱导 Th17 细胞分化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-2 Antibody (S4B6-1) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-2 Antibody (S4B6-1) (100 µg，腹腔注射，每 3 天一次) 在携带 B16F10 肿瘤的雌性 C57BL/6J 小鼠中，与 IL-2 单克隆抗体 (JES6-1A12) (HY-P990219) 联合使用会导致肿瘤生长加速和存活率降低[1]。
Anti-Mouse IL-2 Antibody (S4B6-1) (150 μg，腹腔注射，每 3 天一次，持续 2 周) 可减少携带 B16.Flt3L 肿瘤的 C57BL/6 小鼠的 central Treg cells (cTR) 数量[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 B16F10 cells injected female C57BL/6J mice (8 weeks)[1]
Dosage: 100 µg, combined with IL-2 mAb (JES6-1A12)
Administration: Intraperitoneal injection (i.p.), once every 3 days
Result: Significantly inhibited the expansion of natural killer (NK) cells in tumors.
Accelerated tumor growth and reduced survival rate.
Reduced activation phenotype of host CD4+ T cells (CD25+Foxp3-) in tumors.
Increased Tregs (CD25+ Foxp3+) in tumors.
Animal Model: 3×106 B16.Flt3L cells injected C57BL/6 mice[3]
Dosage: 150 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 2 weeks
Result: Significantly reduced cTR cells without affecting effector Treg cells (eTR).
Inhibited Stat5 phosphorylation.
基因 ID

16183  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse IL-2 Antibody (S4B6-1) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-2 Antibody (S4B6-1)Interleukin RelatedILIL-2CD4T cellsTregsB16Inhibitorinhibitorinhibit

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