Il2 - interleukin 2 Gene

中文名称：白细胞介素 2

种属: Mus musculus

同用名: Il-2

关于 Il2

功能概要

该基因编码的蛋白可启动细胞因子活性和白细胞介素 2 受体结合活性。参与 T 辅助 17 细胞分化的负调节。在几个过程的上游或内部起作用，包括在没有配体的情况下的外在凋亡信号通路；大分子代谢过程的正向调控；和淋巴细胞活化的调节。位于细胞外空间。在肝脏中表达；网膜囊;胸腺;和胸腺原基。用于研究干燥综合征和炎症性肠病。该基因的人类直系同源物与多种疾病有关，包括 Takayasu 动脉炎；听觉系统疾病（多种）；自身免疫性疾病（多种）；癌（多发性）；和神经退行性疾病（多种）。与人 IL2（白细胞介素 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]