2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-2 Antibody (JES6-1A12)

Anti-Mouse IL-2 Antibody (JES6-1A12) 

目录号: HY-P990219 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-2 Antibody (JES6-1A12) 是一种抗小鼠 IL-2 IgG1 单克隆抗体。Anti-Mouse IL-2 Antibody (JES6-1A12) 可以抑制 Treg 扩增并增强 Th1 反应。Anti-Mouse IL-2 Antibody (JES6-1A12) 可以与 IL-2 形成复合物用于实验。Anti-Mouse IL-2 Antibody (JES6-1A12) 可用于研究疟疾等感染疾病。

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Anti-Mouse IL-2 Antibody (JES6-1A12)

Anti-Mouse IL-2 Antibody (JES6-1A12) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥3600
In-stock
10 mg ￥6150
In-stock
50 mg   询价  
100 mg   询价  

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Anti-Mouse IL-2 Antibody (JES6-1A12) 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-2 Antibody (JES6-1A12) is an anti-mouse IL-2 IgG1 monoclonal antibody. Anti-Mouse IL-2 Antibody (JES6-1A12) can inhibit Treg amplification and enhance Th1 response. Anti-Mouse IL-2 Antibody (JES6-1A12) can form a complex with IL-2 for experimentation. Anti-Mouse IL-2 Antibody (JES6-1A12) can be used for research on infection conditions such as malaria[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2]

IL-2

 

体外研究
(In Vitro)

Anti-Mouse IL-2 Antibody (JES6-1A12) (0.2 µg/mL，72 小时) 在慢性感染阶段显著抑制 CD4+ T 细胞的增殖，但在急性感染阶段对增殖没有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-2 Antibody (JES6-1A12) 相关抗体:

Cell Proliferation Assay[1]

Cell Line: CD4+ T cells in the spleen of mice on the 4th day after infection
Concentration: 0.2 µg/mL
Incubation Time: 72 h
Result: Inhibited the proliferation of T cells.
体内研究
(In Vivo)

Anti-Mouse IL-2 Antibody (JES6-1A12) (1 mg/鼠/天，腹腔注射，在第 0, 2 和 4 天) 显著减少了注射了夏氏疟原虫 AS 的雌性 C57BL/6 小鼠的寄生虫血症[1]。
Anti-Mouse IL-2 Antibody (JES6-1A12) (IL-2 与 JES6-1A12 的摩尔比为 2:1，腹腔注射，连续 3 天) 可以与 IL-2 形成复合物从而显著提高 C57BL/6 小鼠对 LPS 的敏感性，诱导 T 细胞扩增并增加脾脏和血液中 CD11b+CD14+ 细胞的数量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×106 infected red blood cells injected female C57BL/6 mice (6-8 weeks)[1]
Dosage: 1 mg/mouse/day
Administration: Intraperitoneal injection (i.p.), on day 0, 2 and 4
Result: Effectively inhibited Treg cell expansion without affecting the activation of effector CD4+ T cells or IFN-γ production.
Increased the levels of TNF-α and malaria parasite specific IgG2a antibodies and enhances protective immunity.
Significantly reduced parasitic infections by about 40 %.
基因 ID

16183  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-2 Antibody (JES6-1A12) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-2 Antibody (JES6-1A12)Interleukin RelatedILIL-2TregTh1malariaPlasmodium chabaudi ASInhibitorinhibitorinhibit

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