2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Bacterial Reactive Oxygen Species (ROS)
  4. Anti-MRSA agent 33 iodide

Anti-MRSA agent 33 iodide 是一种抗耐甲氧西林 (Methicillin (HY-121544)) 金黄色葡萄球菌 (MRSA) 剂，其 MIC 值为 2-4 μg/mL。Anti-MRSA agent 33 iodide 表现出有效的生物膜根除能力性并且对哺乳动物细胞的细胞毒性极小。Anti-MRSA agent 33 iodide 特异性结合细菌膜上的磷脂酰甘油 (PG)，导致膜破坏、活性氧 (ROS) 过量产生和代谢崩溃，最终导致细菌细胞死亡。Anti-MRSA agent 33 iodide 在小鼠皮肤感染模型中降低了细菌载量。

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Anti-MRSA agent 33 iodide

Anti-MRSA agent 33 iodide Chemical Structure

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Anti-MRSA agent 33 iodide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-MRSA agent 33 iodide is an anti-Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) agent, with MIC values of 2-4 μg/mL. Anti-MRSA agent 33 iodide demonstrates effective biofilm eradication and minimal cytotoxicity toward mammalian cells. Anti-MRSA agent 33 iodide specifically binds to phosphatidylglycerol (PG) on bacterial membranes, leading to membrane disruption, excessive production of ROS, and metabolic collapse, ultimately resulting in bacterial cell death. Anti-MRSA agent 33 iodide reduces bacterial load in a murine skin infection model[1].

体外研究
(In Vitro)

Anti-MRSA agent 33 iodide (Compound IV4) (16-20 h) 对金黄色葡萄球菌 (S. aureus) ATCC 29213、耐甲氧西林金黄色葡萄球菌 (MRSA) N315 以及 10 株临床耐甲氧西林金黄色葡萄球菌分离株 (M22、M17、M16、M23、M14、M13、M11、M21、M12 和 M20) 具有抗菌活性，最低抑菌浓度 (MIC) 值为 2-4 μg/mL[1]。
Anti-MRSA agent 33 iodide (8-32 μg/mL, 3-6 h) 对金黄色葡萄球菌 (S. aureus) ATCC 29213 和耐甲氧西林金黄色葡萄球菌 (MRSA) N315 具有快速杀菌活性，且耐药诱导潜力较低[1]。
Anti-MRSA agent 33 iodide (2-16 μg/mL, 3-6 h) 具有破坏细菌生物膜的作用 (针对金黄色葡萄球菌 (S. aureus) ATCC 29213 和耐甲氧西林金黄色葡萄球菌 (MRSA) N315)[1]。
Anti-MRSA agent 33 iodide (2-128 μg/mL) 具有优异的安全性特征，对 RAW 264.7 细胞和 NIH 3T3 细胞的半数抑制浓度 (IC50) 值分别为 22.48 μg/mL 和 27.45 μg/mL[1]。
Anti-MRSA agent 33 iodide (4-64 μg/mL) 可特异性结合细菌细胞膜上的磷脂酰甘油 (PG)，导致膜破坏、活性氧 (ROS) 过量产生和代谢崩溃，最终导致细菌细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 33 iodide 相关抗体:

Apoptosis Analysis[1]

Cell Line: MRSA N315
Concentration: 4, 8, 16, 32, 64 μg/mL
Incubation Time: 4 h
Result: Showed complete membrane destruction and bacterial death.

Real Time qPCR[1]

Cell Line: MRSA N315
Concentration: 8 μg/mL
Incubation Time: 2 h
Result: Inhibited the expression of amaP, qoxA, qoxB, and atpB.
Upregulated the levels of ahpC.
体内研究
(In Vivo)

Anti-MRSA agent 33 iodide (Compound IV4) (5-10 mg/kg，皮下注射，单次给药) 在小鼠皮肤感染模型中可减少细菌载量并减轻炎症，且无全身毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice aged 6-8 weeks were subcutaneously inoculated with MRSA suspension (6 × 108 cfu/mL)[1]
Dosage: 5, 10 mg/kg
Administration: Subcutaneously administered for a single dose after MRSA suspension 4 h
Result: Showed smooth skin surface at the infection site and prevented obvious inflammatory cell infiltration in both the epidermis and dermis.
Reduced IL-6 and TNF-α levels.
Showed no pathological changes (inflammation/necrosis/hemorrhage) in the heart, lungs, spleen, or kidneys, with normal tissue architecture and cell arrangement.
分子量

682.60

Formula

C35H35IN6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-MRSA agent 33 iodide 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 33BacterialReactive Oxygen Species (ROS)phosphatidylglycerolROSStaphylococcus aureusBacteriaInhibitorinhibitorinhibit

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