Rab5a 抗体 (YA6233)

Rab5a Antibody (YA6233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab5a.

Rab 5A 属于小 GTPases Rab 家族，是细胞内膜运输的关键调节因子，参与从运输囊泡形成到与膜融合的全过程。它通过 GDP 结合（失活）和 GTP 结合（激活）状态循环发挥作用，激活状态下可募集下游效应因子，直接调控囊泡形成、运动、锚定和融合。RAB5A 是质膜与早期内体融合所必需的，并参与调控丝状伪足延伸。此外，它还介导 SDCBP、CD63、PDCD6IP 和 syndecan 的外泌体释放。根据相似性研究推测，Rab 5A 可能通过 DYN2 和 PIK3C3 下游通路调控凋亡细胞吞噬体的成熟。

P20339

Predicted band size: 24 kDa; Observed band size: 24 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:4000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

液体

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG