2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Reactive Oxygen Species Ferroptosis Apoptosis
  4. Anticancer agent 154

Anticancer agent 154 (Compound 8h) 会增加活性氧的水平并导致线粒体损伤。Anticancer agent 154 诱导细胞凋亡 (apoptosis) 和 DNA 损伤。Anticancer agent 154 还通过降低 GSH 水平和 GPX4 表达以及增加脂质过氧化水平来诱导铁死亡 (ferroptosis)。Anticancer agent 154 抑制癌细胞 (HT29、H1975、A549 和 MCF-7) 增殖，IC50s 为 1.0-1.9 μM。

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Anticancer agent 154 Chemical Structure

Anticancer agent 154 Chemical Structure

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Anticancer agent 154 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC50s of 1.0-1.9 μM[1].

分子量

389.45

Formula

C22H23N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 154 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 154Anticancer agent154Anticancer agent-154Reactive Oxygen SpeciesFerroptosisApoptosiscancerHT29H1975A549MCF-7mitochondrial damageDNA damageInhibitorinhibitorinhibit

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