2. Apoptosis
  3. Apoptosis Ferroptosis
  4. Anticancer agent 199

Anticancer agent 199 (Compound G-4) 通过抑制 EGFR、AKT 和 MAPK 途径，以及线粒体途径诱导三阴性乳腺癌 (TNBC) 细胞凋亡 (Apoptosis)。Anticancer agent 199 还通过下调 LCN2 诱导铁死亡 (Ferroptosis)。Anticancer agent 199 抑制 TNBC 细胞活力和迁移，并诱导 S 期细胞周期停滞。Anticancer agent 199 是细胞周期蛋白依赖性激酶抑制剂 Rocovitine 的衍生物。

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Anticancer agent 199

Anticancer agent 199 Chemical Structure

CAS No. : 2422001-24-7

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Anticancer agent 199 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 199 (Compound G-4) induces apoptosis in triple negative breast cancer (TNBC) cells via the mitochondrial pathway through inhibiting EGFR, AKT and MAPK pathways. Anticancer agent 199 also induces Ferroptosis by down-regulating LCN2. Anticancer agent 199 inhibits TNBC cell viability and migration, and induces S phase cell cycle arrest. Anticancer agent 199 is a derivate of cyclin-dependent kinase inhibitor Rocovitine[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.54 μM
Compound: 3i
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
HCT-116 IC50
2.95 μM
Compound: 3i
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
HT-29 IC50
4.21 μM
Compound: 3i
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
HepG2 IC50
1.75 μM
Compound: 3i
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
K562 IC50
2.63 μM
Compound: 3i
Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
MCF7 IC50
2.83 μM
Compound: 3i
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
MGC-803 IC50
19.89 μM
Compound: 3i
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
NCI-H1299 IC50
4.77 μM
Compound: 3i
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
PC-3 IC50
7.2 μM
Compound: 3i
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 37708799]
分子量

556.12

Formula

C29H39ClFN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 199 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1992422001-24-7Anticancer agent199Anticancer agent-199ApoptosisFerroptosisTNBCbreast canceranticancerRocovitineInhibitorinhibitorinhibit

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