2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Parasite Reactive Oxygen Species (ROS) Apoptosis
  4. Antileishmanial agent-36

Antileishmanial agent-36 (compound 4f) 是一种具有抗利什曼活性 (anti-leishmanial) 的吲哚-二氢嘧啶酮衍生物。Antileishmanial agent-36 能够诱导活性氧 (ROS) 介导的线粒体功能障碍和细胞凋亡 (apoptosis)。Antileishmanial agent-36 对杜氏利什曼原虫展现出强效活性 (IC50 =4.54 μM)，同时对 J774.1 巨噬细胞的细胞毒性较低。Antileishmanial agent-36 在内脏利什曼病 (VL) 模型中能够清除寄生虫负荷。Antileishmanial agent-36 可用于内脏利什曼病的相关研究。

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Antileishmanial agent-36

Antileishmanial agent-36 Chemical Structure

CAS No. : 3086122-36-0

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Antileishmanial agent-36 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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生物活性

Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research[1].

分子量

417.50

Formula

C24H27N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antileishmanial agent-36 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antileishmanial agent-363086122-36-0Antileishmanial agent36Antileishmanial agent 36ParasiteReactive Oxygen Species (ROS)Apoptosisanti-leishmanialROSL. donovaniJ774.1 macrophageVLInhibitorinhibitorinhibit

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