2. Anti-infection
  3. Parasite
  4. Antimalarial agent 12

Antimalarial agent 12 (compound R-3b) 是一种有效的抗疟 (antimalarial) 药。Antimalarial agent 12 抑制恶性疟原虫 Dd2 菌株 (EC50=155 nM)、3D7 菌株 (EC50=136 nM) 生长。Antimalarial agent 12 对 HEK-293 和 hPHep 细胞系的 CC50 值为 10,000-50,000 nM。Antimalarial agent 12 对大肠杆菌的 MIC 为 > 250,000 nM。

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Antimalarial agent 12 Chemical Structure

Antimalarial agent 12 Chemical Structure

CAS No. : 2715225-58-2

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Antimalarial agent 12 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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生物活性

Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli[1].

IC50 & Target

Plasmodium

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 CC50
> 50000 nM
Compound: (R)-3b
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
[PMID: 35300082]
Hepatocyte CC50
> 10000 nM
Compound: (R)-3b
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
[PMID: 35300082]
分子量

505.79

Formula

C26H18BrClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 122715225-58-2Antimalarial agent12Antimalarial agent-12ParasiteAntimalarialP. falciparumDd2 Strain3D7 strainHEK-293hPHepEscherichia coliInhibitorinhibitorinhibit

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