2. Anti-infection Protein Tyrosine Kinase/RTK
  3. Parasite Ephrin Receptor
  4. Antimalarial agent 37

Antimalarial agent 37（compound 33）是一种针对 II 型激酶的选择性抑制剂，具有抗疟原虫活性。Antimalarial agent 37 对癌细胞 HepG2 和 MCF7 具有细胞毒性和选择性。

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Antimalarial agent 37

Antimalarial agent 37 Chemical Structure

CAS No. : 2982633-16-7

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Antimalarial agent 37 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
2850 nM
Compound: 33
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 38214254]
MCF7 EC50
3540 nM
Compound: 33
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 38214254]
体外研究
(In Vitro)

Antimalarial agent 37（0-50 nM，72 h）具有抗疟原虫活性，对于菌株 Dd2 和 3D7 的 EC50值是 31 nM 和 35 nM[1]。
Antimalarial agent 37 具有微粒体稳定性，在小鼠肝微粒体中的半衰期是 41.4 min，清除率是 17 μL/min/mg [1]。
Antimalarial agent 37（0-5000 nM，48 h）对于细胞 HepG2 和 MCF7 具有细胞毒性，EC50 值是 2850 和 3540 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 37 相关抗体:

Cell Proliferation Assay[1]

Cell Line: P. falciparum Dd2 and P. falciparum 3D7 strains
Concentration: 0-50 nM
Incubation Time: 72 h
Result: Exhibited antiplasmodial activities with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7.

Cell Viability Assay[1]

Cell Line: HepG2, MCF7
Concentration: 0-5000 nM
Incubation Time: 48 h
Result: Revealed cytotoxicity in HepG2 and MCF7, with EC50 values of 2850 nM and 3540 nM as well as selectivity index of 92 and 114, respectively
分子量

661.66

Formula

C32H29F6N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 37 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antimalarial agent 372982633-16-7Antimalarial agent37Antimalarial agent-37ParasiteEphrin ReceptorantimalarialP. falciparumHepG2MCF7Inhibitorinhibitorinhibit

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