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  4. Antitrypanosomal agent 5

Antitrypanosal agent 5 (Compound 25) 是一种选择性的抗锥虫剂，对 T. brucei 和 HEK293 细胞生长的 IC50 分别为 1 nM 和 483.3 µM。

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Antitrypanosomal agent 5

Antitrypanosomal agent 5 Chemical Structure

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Antitrypanosomal agent 5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
483.3 μM
Compound: 25
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 35396128]
RAW264.7 IC50
> 500 μM
Compound: 25
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 35396128]
体外研究
(In Vitro)

After dosing T. brucei cells with Antitrypanosomal agent 5 (Compound 25; 200-1000 nM) for 12 hours, Western blot analyses shows Antitrypanosomal agent 5 inhibits tubulin polymerization in T. brucei cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 5 相关抗体:

Western Blot Analysis

Cell Line: T. brucei cells[1]
Concentration: 200nM; 500 nM; 1000 nM
Incubation Time: 12 hours
Result: Polymerized tubulin in T. brucei cells was significantly decreased with the treatment of Antitrypanosomal agent 5 at 500 nM and 1000 nM.
分子量

570.66

Formula

C30H30N6O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitrypanosomal agent 5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 5Antitrypanosomal agent5Antitrypanosomal agent-5Parasiteanti-trypanosomalT. bruceiHEK293Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-146071
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