Apoptosis inducer 12

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Apoptosis inducer 12 (Compound 3z) 是一种通过线粒体途径诱导凋亡 (apoptosis) 的凋亡诱导剂，可用于癌症的研究。

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Apoptosis inducer 12 Chemical Structure

CAS No. : 1971096-01-1

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生物活性

Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.52 μM Compound: 3z	Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-0 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
A498	GI₅₀	0.36 μM Compound: 3z	Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A498 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
A549	GI₅₀	0.95 μM Compound: 3z	Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
ACHN	GI₅₀	0.69 μM Compound: 3z	Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human ACHN cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
BT-549	GI₅₀	0.25 μM Compound: 3z	Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human BT-549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
CAKI-1	GI₅₀	0.58 μM Compound: 3z	Antiproliferative activity against human CAKI-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human CAKI-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
CCRF-CEM	GI₅₀	0.44 μM Compound: 3z	Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human CCRF-CEM cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
COLO 205	GI₅₀	0.38 μM Compound: 3z	Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human COLO 205 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
DU-145	GI₅₀	0.84 μM Compound: 3z	Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
EKVX	GI₅₀	2.67 μM Compound: 3z	Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human EKVX cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HBL1	IC₅₀	0.5 μM Compound: 3z	Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 37068384]
HCC 2998	GI₅₀	1.66 μM Compound: 3z	Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HCC 2998 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HCT-116	GI₅₀	0.4 μM Compound: 3z	Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HCT-15	GI₅₀	0.53 μM Compound: 3z	Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-15 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HL-60(TB)	GI₅₀	0.3 μM Compound: 3z	Antiproliferative activity against human HL-60(TB) cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60(TB) cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HOP-62	GI₅₀	0.69 μM Compound: 3z	Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HOP-62 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HOP-92	GI₅₀	0.52 μM Compound: 3z	Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HOP-92 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
HT-29	GI₅₀	0.42 μM Compound: 3z	Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
Hs-578T	GI₅₀	0.4 μM Compound: 3z	Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human Hs-578T cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
IGROV-1	GI₅₀	1.56 μM Compound: 3z	Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human IGROV-1 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
K562	GI₅₀	0.39 μM Compound: 3z	Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
KM12	GI₅₀	0.56 μM Compound: 3z	Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human KM12 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
LOX IMVI	GI₅₀	0.7 μM Compound: 3z	Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human LOX IMVI cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
M14	GI₅₀	0.48 μM Compound: 3z	Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human M14 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
MCF7	GI₅₀	0.42 μM Compound: 3z	Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
MDA-MB-231	GI₅₀	1.15 μM Compound: 3z	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
MDA-MB-435	GI₅₀	0.24 μM Compound: 3z	Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
MDA-MB-468	GI₅₀	0.65 μM Compound: 3z	Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
MOLT-4	GI₅₀	0.65 μM Compound: 3z	Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MOLT-4 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI-H226	GI₅₀	2.54 μM Compound: 3z	Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H226 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI-H23	GI₅₀	1.34 μM Compound: 3z	Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H23 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI-H322M	GI₅₀	0.84 μM Compound: 3z	Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H322M cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI-H460	GI₅₀	0.4 μM Compound: 3z	Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI-H522	GI₅₀	0.26 μM Compound: 3z	Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H522 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
NCI/ADR-RES	GI₅₀	0.6 μM Compound: 3z	Antiproliferative activity against human NCI-ADR-RES cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-ADR-RES cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
OVCAR-5	GI₅₀	1.44 μM Compound: 3z	Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human OVCAR-5 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
OVCAR-8	GI₅₀	1.57 μM Compound: 3z	Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
PBL	IC₅₀	> 10 μM Compound: 3z	Cytotoxicity against PHA-induced human PBL cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against PHA-induced human PBL cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37068384]
PBL	IC₅₀	> 10 μM Compound: 3z	Cytotoxicity against resting human PBL cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against resting human PBL cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 37068384]
PC-3	GI₅₀	0.43 μM Compound: 3z	Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
RPMI-8226	GI₅₀	0.61 μM Compound: 3z	Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
RXF 393	GI₅₀	0.45 μM Compound: 3z	Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human RXF 393 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SF-268	GI₅₀	1.45 μM Compound: 3z	Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SF-268 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SF-295	GI₅₀	0.5 μM Compound: 3z	Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SF-295 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SF-539	GI₅₀	0.4 μM Compound: 3z	Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SF-539 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SK-MEL-28	GI₅₀	2.93 μM Compound: 3z	Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SK-MEL-5	GI₅₀	1.13 μM Compound: 3z	Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SK-OV-3	GI₅₀	0.68 μM Compound: 3z	Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SN12C	GI₅₀	0.84 μM Compound: 3z	Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SN12C cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SNB-19	GI₅₀	0.81 μM Compound: 3z	Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SNB-19 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SNB-75	GI₅₀	0.38 μM Compound: 3z	Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SNB-75 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SR	GI₅₀	0.36 μM Compound: 3z	Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SR cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
SU-DHL10	IC₅₀	0.5 μM Compound: 3z	Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 37068384]
SW-620	GI₅₀	0.43 μM Compound: 3z	Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SW-620 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
T47D	GI₅₀	0.39 μM Compound: 3z	Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human T47D cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
TK-10	GI₅₀	96.6 μM Compound: 3z	Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human TK-10 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
U-251	GI₅₀	0.51 μM Compound: 3z	Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human U-251 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]
UACC-257	GI₅₀	0.58 μM Compound: 3z	Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by assay Antiproliferative activity against human UACC-257 cells assessed as growth inhibition incubated for 72 hrs by assay	[PMID: 37068384]
UACC-62	GI₅₀	0.43 μM Compound: 3z	Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by assay Antiproliferative activity against human UACC-62 cells assessed as growth inhibition incubated for 72 hrs by assay	[PMID: 37068384]
UO-31	GI₅₀	0.69 μM Compound: 3z	Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human UO-31 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37068384]

体外研究
(In Vitro)

Apoptosis inducer 12 (Compound 3z; 72 h) 对 9 种人类肿瘤细胞 (白血病、非小细胞肺癌、结肠癌、中枢神经系统、黑色素瘤、卵巢癌、肾癌、前列腺癌和乳腺癌) 具有抗增殖活性，GI₅₀ 为 0.24-96.6 μM。白血病和前列腺细胞系对 Apoptosis inducer 12 的反应特别明显，GI₅₀ 值分别为 0.30-0.65 μM 和 0.43-0.84 μM ^[1]。
Apoptosis inducer 12 (0.5-10 μM; 24 h) 阻断 A549、CCRF-CEM 和 VL51 细胞的中期细胞周期^[1]。
Apoptosis inducer 12 (0.5-5 μM; 48 h) 诱导 A549、CCRF-CEM 和 VL51 细胞凋亡^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	A549, CCRF-CEM and VL51
Concentration:	0.5, 1, 5 and 10 μM
Incubation Time:	24 h
Result:	Induced a block in G2/M accompanied by a strong decrease in S phase cells.

Apoptosis Analysis^[1]

Cell Line:	A549, CCRF-CEM and VL51
Concentration:	0.5, 1 and 5 μM
Incubation Time:	48 h
Result:	Induced massive apoptosis in a dose-dependent manner.

分子量

475.54

Formula

C₂₇H₂₉N₃O₅

CAS 号

1971096-01-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Barreca M, et al. Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas. Eur J Med Chem. 2023 Jun 5;254:115372. [Content Brief]

Apoptosis inducer 12 相关分类

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质量		浓度		体积		分子量 *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 121971096-01-1Apoptosis inducer12Apoptosis inducer-12ApoptosisMDA-MB-435BT-549NCI–H522A549CCRF-CEMVL51Inhibitorinhibitorinhibit

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