2. Anti-infection
  3. Filovirus
  4. As-358 hydrochloride

As-358 (hydrochloride) 对埃博拉病毒 (Ebola virus) 和马尔堡病毒 (Marburg virus) 具有抑制活性，IC50 分别为 9.1 μM 和 18.1 μM，同时也具有良好的体内安全性。

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As-358 hydrochloride Chemical Structure

As-358 hydrochloride Chemical Structure

CAS No. : 2374723-26-7

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Other Forms of As-358 hydrochloride:

As-358 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].

IC50 & Target

IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1]
体外研究
(In Vitro)

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

As-358 hydrochloride 相关抗体:

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
体内研究
(In Vivo)

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg
Administration: IG; single (observed for 7 days)
Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
分子量

329.91

Formula

C18H32ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

As-358 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

As-3582374723-26-7As358As 358FilovirusEbola virusMarburg virusLow toxicityICR miceInhibitorinhibitorinhibit

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As-358 hydrochloride
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