2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. ASIC-IN-1

ASIC-IN-1 是一种有效的酸感应离子通道 (acid sensing ion channel) 抑制剂，IC50 值为 < 10 µM。ASIC-IN-1 导致疼痛强度的剂量依赖性降低。

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ASIC-IN-1 Chemical Structure

ASIC-IN-1 Chemical Structure

CAS No. : 308088-10-0

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ASIC-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1].

IC50 & Target

IC50: < 10 µM (acid sensing ion channel)[1]
体内研究
(In Vivo)

ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 150-180 g male Sprague-Dawley rats[1]
Dosage: 50 mg/kg
Administration: I.p.
Result: Blocked acute tonic pain induced by formalin injection in the paw.
分子量

375.46

Formula

C23H25N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ASIC-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASIC-IN-1308088-10-0Sodium ChannelNa channelsNa+ channelspain intensityInhibitorinhibitorinhibit

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产品名称：
ASIC-IN-1
目录号：
HY-147391
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