1. MAPK/ERK Pathway Apoptosis
  2. MAP3K Apoptosis
  3. ASK1-IN-3

ASK1-IN-3 是一种有效且具有选择性的 ASK1 激酶抑制剂,IC50 为 33.8 nM,同时也抑制多种细胞周期调节激酶。ASK1-IN-3 具有较强的 HepG2 癌细胞凋亡 (apoptosis) 诱导活性与有效的细胞周期阻滞活性。

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ASK1-IN-3 Chemical Structure

ASK1-IN-3 Chemical Structure

CAS No. : 2426705-19-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

IC50 & Target

IC50: 33.8 nM (ASK1)[1]

体外研究
(In Vitro)

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line: HepG2[1]
Concentration: 10, 20 and 50 μM
Incubation Time: 48 hours
Result: Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line: HepG2[1]
Concentration: 1, 2, 4, 8, and 16 μM
Incubation Time: 24 hours
Result: Significantly arrested cycle progression at G1 phase.
分子量

378.39

Formula

C18H18N8O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

ASK1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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