1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. ATP dipotassium

ATP dipotassium (Synonyms: Adenosine 5'-triphosphate dipotassium)

目录号: HY-B2176C
产品使用指南

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATP dipotassium 是免疫和炎症中重要的内源性信号分子。

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ATP dipotassium Chemical Structure

ATP dipotassium Chemical Structure

CAS No. : 42373-41-1

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ATP dipotassium 的其他形式现货产品:

ATP

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Description

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2].

In Vitro

ATP dipotassium (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP dipotassium stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].

In Vivo

ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP dipotassium induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model: Four-week-old Kunming mice (18-22 g)[4]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
Result: Protected mice from bacterial infection.
Molecular Weight

583.36

Formula

C₁₀H₁₄K₂N₅O₁₃P₃

CAS No.

42373-41-1

中文名称

腺苷三磷酸二钾

SMILES

O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(OP(O)(O[K])=O)(O[K])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ATP dipotassiumAdenosine 5'-triphosphate dipotassiumEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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