2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Barnidipine

Barnidipine  (Synonyms: Mepirodipine; YM-09730-5 Free base)

目录号: HY-107322A
产品使用指南 技术支持

Barnidipine (Mepirodipine) 是一种 L 型钙拮抗剂 (CaA)，对 [3H] initrendipine 结合位点具有高亲和力 (Ki = 0.21 nmol/L)，对 CaA 受体具有选择性作用。Barnidipine 是口服有效的抗高血压剂，可以降低血小板衍生生长因子 B 链 mRNA 的水平和减少外周血管阻力。

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Barnidipine

Barnidipine Chemical Structure

CAS No. : 104713-75-9

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规格 价格 是否有货 数量
1 mg ￥335
1 - 2 周
5 mg ￥790
1 - 2 周
10 mg ￥1185
1 - 2 周
25 mg ￥2375
1 - 2 周
50 mg   询价  
100 mg   询价  

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Other Forms of Barnidipine:

Barnidipine 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3].

IC50 & Target

L-type calcium channel

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LLC-PK1 IC50
12.6 μM
Compound: Barnidipine
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 12128170]
LLC-PK1 IC50
8.6 μM
Compound: Barnidipine
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11145223]
Oocyte IC50
1.2 μM
Compound: Barnidipine
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit
[PMID: 22761000]
Oocyte IC50
3.1 μM
Compound: Barnidipine
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Xenopus oocyte heterologically expressing alpha-1C subunit
[PMID: 22761000]
体内研究
(In Vivo)

盐形式剂量：
Barnidipine hydrochloride (53 mg/kg；饲料给药；3 周) 在自发性高血压大鼠中可以降低血小板衍生生长因子 B 链 mRNA 的水平，具有降血压的作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SHR aged 13 weeks old[3]
Dosage: Salt form dose: 0.6 mg/g of food (average dose: 53 mg/kg of body mass/day)
Administration: Feed administration; 3 weeks
Result: Reduced systolic blood pressure steadily after week 1 of therapy.
Did not change renal histology after week 3 of therapy.
Significantly reduced the level of expression of PDGF B-chain mRNA in glomeruli.
Significantly reduced the excretion of urinary protein.
分子量

491.54

Formula

C27H29N3O6
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

巴尼地平
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Barnidipine 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Barnidipine104713-75-9MepirodipineYM-09730-5巴尼地平Calcium ChannelCa2+ channelsCa channelsCalcium Channel AntagonistSHRInhibitorinhibitorinhibit

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