2. GPCR/G Protein Protein Tyrosine Kinase/RTK
  3. Arf Family GTPase BMX Kinase
  4. Brefeldin A 4-O-nicotinate

Brefeldin A 4-O-nicotinate  (Synonyms: CHNQD-01228)

目录号: HY-173280
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Brefeldin A 4-O-nicotinate (CHNQD-01228) 是一种 Arf1 和 BMX 蛋白的双重抑制剂，对 T24 细胞增殖的 IC50 值为 0.22 μM，还能剂量依赖性抑制 T24 细胞迁移和集落形成、诱导 G1 期阻滞并触发细胞凋亡 (Apoptosis)；Brefeldin A 4-O-nicotinate 通过靶向 BMX 蛋白抑制 AKT/p-AKT 和 STAT3/p-STAT3 信号通路，以及抑制 Arf1 蛋白来消除膀胱癌干细胞、激活抗肿瘤免疫，从而发挥抗癌活性。Brefeldin A 4-O-nicotinate 可用于膀胱癌相关领域的研究。

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Brefeldin A 4-O-nicotinate

Brefeldin A 4-O-nicotinate Chemical Structure

CAS No. : 3035018-34-6

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Brefeldin A 4-O-nicotinate 相关抗体

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  • 生物活性

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生物活性

Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer[1].

分子量

385.45

Formula

C22H27NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Brefeldin A 4-O-nicotinate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Brefeldin A 4-O-nicotinate3035018-34-6CHNQD-01228CHNQD01228CHNQD 01228Arf Family GTPaseBMX KinaseADP-ribosylation Factor (ARF) Family GTPaseInhibitorinhibitorinhibit

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