2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. c-Fms-IN-15

c-Fms-IN-15 (compound 8g) 是 FMS 激酶 (FMS kinase) 的有效抑制剂，IC50 为 563 nM。

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c-Fms-IN-15

c-Fms-IN-15 Chemical Structure

CAS No. : 3047930-25-3

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c-Fms-IN-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with the IC50 of 563 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BMDM IC50
56 nM
Compound: 8g
Inhibition of CSF-1-induced C57BL6 mouse BMDM cell growth preincubated for 1 hr followed by CSF-1 addition and measured after 5 hrs by alamar blue assay
Inhibition of CSF-1-induced C57BL6 mouse BMDM cell growth preincubated for 1 hr followed by CSF-1 addition and measured after 5 hrs by alamar blue assay
[PMID: 38850857]
HS27 IC50
9.4 μM
Compound: 8g
Cytotoxicity against human HS27 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HS27 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
[PMID: 38850857]
Hep 3B2 IC50
1.63 μM
Compound: 8g
Antiproliferative activity against human Hep3B cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 38850857]
HepG2 IC50
1.48 μM
Compound: 8g
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 38850857]
WI-38 IC50
19.1 μM
Compound: 8g
Cytotoxicity against human WI-38 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell growth measured after 48 hrs by MTT assay
[PMID: 38850857]
分子量

563.57

Formula

C29H28F3N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Fms-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Fms-IN-153047930-25-3c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RHCC cellsHep3B cellsInhibitorinhibitorinhibit

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