2. Autophagy
  3. Autophagy
  4. CDC20-IN-1

CDC20-IN-1 (Compound E1) 是一种 CDC20 的特异性抑制剂，可用于三阴性乳腺癌的研究。CDC20-IN-1 可诱导癌细胞的自噬，抑制 MDA-MB-231细胞增殖，IC50 值为 1.43 μM。

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CDC20-IN-1

CDC20-IN-1 Chemical Structure

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CDC20-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDC20-IN-1 (Compound E1) is a specific inhibitor of CDC20 and can be used in triple-negative breast cancer research. CDC20-IN-1 can induce autophagy in cancer cells and inhibit MDA-MB-231 cell proliferation, with an IC50 value of 1.43 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
6.47 μM
Compound: E1
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 38364716]
L02 IC50
14.66 μM
Compound: E1
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 38364716]
MCF7 IC50
3.27 μM
Compound: E1
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 38364716]
MDA-MB-231 IC50
1.43 μM
Compound: E1
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 38364716]
MDA-MB-468 IC50
7.24 μM
Compound: E1
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 38364716]
分子量

518.78

Formula

C19H22Cl3N7O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDC20-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDC20-IN-1AutophagyApcin analogueCell cycleAntitumorInhibitorinhibitorinhibit

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