1. Anti-infection
  2. Bacterial
    HBV
  3. Cetylpyridinium chloride

Cetylpyridinium chloride 

目录号: HY-B1464 纯度: >98.0%
产品使用指南

Cetylpyridinium chloride,一种阳离子季铵化合物,是一种具有广谱活性的抗菌剂。Cetylpyridinium chloride 是一种有效的抗 HBV 衣壳装配抑制剂,IC50 为 2.5 μM。Cetylpyridinium chloride 被用于杀虫剂和各种漱口水以及其他个人护理产品中。

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Cetylpyridinium chloride Chemical Structure

Cetylpyridinium chloride Chemical Structure

CAS No. : 123-03-5

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
50 mg ¥500 In-stock
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Description

Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products[1][2].

IC50 & Target

IC50: 2.5 μM (HBV capsid assembly)[1]

In Vitro

Cetylpyridinium chloride interacts with dimeric viral nucleocapsid protein (known as core protein or HBcAg) specifically. Compared with other HBV inhibitors, Cetylpyridinium chloride achieves significantly better reduction of HBV particle number in HepG2.2.15 cell line. Cetylpyridinium chloride inhibits capsid assembly and leads to reduced HBV biogenesis[1].
Cetylpyridinium chloride is a safe antimicrobial agent with broad-spectrum activity for preventing biofilm formation and gingivitis[2].

In Vivo

Cetylpyridinium chloride (30 μg/kg; intramuscular injection; daily; for 3 days; male C57BL/6 mice) treatment inhibits HBV replication in mouse hydrodynamic model system[1].

Animal Model: Male C57BL/6 mice (6-week old) injected with the plasmid [1]
Dosage: 272 μg/kg/day
Administration: Intramuscular injection; daily; for 3 days
Result: Suppressed serum HBV DNA levels, decreased by 60% in day2 and 45% in day3 compared to the control.
Molecular Weight

339.99

Formula

C₂₁H₃₈ClN

CAS No.

123-03-5

中文名称

西吡氯铵; 氯化十六烷吡啶;氯化十六烷基吡啶翁

SMILES

CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (294.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9413 mL 14.7063 mL 29.4126 mL
5 mM 0.5883 mL 2.9413 mL 5.8825 mL
10 mM 0.2941 mL 1.4706 mL 2.9413 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CetylpyridiniumBacterialHBVHepatitis B virusCapsidassemblyanti-bacterialreplicationcationicquaternaryammoniumpesticidesmouthwashesInhibitorinhibitorinhibit

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