Chelidonine hydrochloride

目录号: HY-N2369A: FAQs
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Chelidonine (hydrochloride) 是Chelidonine (HY-N2369) 的盐酸盐形式。Chelidonine 是一种异喹啉生物碱，可从白屈菜中提取出。Chelidonine 能导致细胞周期 G_2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡 (apoptosis)，也能阻止 Dugesia japonica 的干细胞细胞周期进程。Chelidonine 对黑色素细胞瘤具有细胞毒性活性。具有抗肿瘤和抗病毒活性.。

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Chelidonine hydrochloride Chemical Structure

CAS No. : 4312-31-6

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Chelidonine hydrochloride 的其他形式现货产品:

Chelidonine

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Chelidonine In-stock

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50 mg		询价
100 mg		询价
250 mg		询价

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生物活性

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参考文献

生物活性

Chelidonine (hydrochloride) is the hydrochloride form of Chelidonine (HY-N2369).Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity^[1]^[2]^[3].

分子量

389.83

Formula
C₂₀H₂₀ClNO₅

CAS 号
4312-31-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (543 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179. [Content Brief]

[2]. Isolani ME, et al. The in vivo effect of chelidonine on the stem cell system of planarians. Eur J Pharmacol. 2012 Jul 5;686(1-3):1-7. [Content Brief]

[3]. Hammerová J, et al. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 2011 Apr;62(1):22-35. [Content Brief]

[1]. Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179.

[2]. Isolani ME, et al. The in vivo effect of chelidonine on the stem cell system of planarians. Eur J Pharmacol. 2012 Jul 5;686(1-3):1-7.

[3]. Hammerová J, et al. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 2011 Apr;62(1):22-35.

Chelidonine hydrochloride 相关分类

Apoptosis Anti-infection

Apoptosis Influenza Virus

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量浓度体积分子量 *

= × ×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start) × 体积 _(start) = 浓度 _(final) × 体积 _(final)

× = ×

C1 V1 C2 V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Chelidonine4312-31-6ApoptosisInfluenza Virusisoquinoline alkaloidanticancerantiviralmelanoma cellDugesia japonicaA-375Inhibitorinhibitorinhibit

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生物活性	Chelidonine (hydrochloride) is the hydrochloride form of Chelidonine (HY-N2369).Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity^[1]^[2]^[3].
分子量	389.83
Formula	C₂₀H₂₀ClNO₅
CAS 号	4312-31-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (543 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179. [Content Brief] [2]. Isolani ME, et al. The in vivo effect of chelidonine on the stem cell system of planarians. Eur J Pharmacol. 2012 Jul 5;686(1-3):1-7. [Content Brief] [3]. Hammerová J, et al. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 2011 Apr;62(1):22-35. [Content Brief]

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

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Chelidonine hydrochloride

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