2. Anti-infection
  3. Bacterial
  4. CHIR-29498

CHIR-29498 是一种抗菌肽。CHIR-29498 对革兰氏阳性菌和革兰氏阴性菌均有活性。CHIR-29498 可用于研究致命性金黄色葡萄球菌。

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CHIR-29498

CHIR-29498 Chemical Structure

CAS No. : 236102-25-3

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CHIR-29498 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus[1].

体外研究
(In Vitro)

CHIR-29498 (0.6-40 μM，18-24 小时) 对革兰氏阳性菌和革兰氏阴性菌均有活性[1]。
CHIR-29498 (20-40 μM) 可持续增加大肠杆菌 ML-35 (ATCC 43827) 的细胞外 β-半乳糖苷酶活性，表明细胞膜泄漏[1]。
CHIR-29498 (20-40 μM，0.5-2 小时) 孵育 30 分钟后，54.4% (1× MIC) 和 74.2% (2× MIC) 的金黄色葡萄球菌 ATCC 25923 被 PI 染色；2 小时后，染色率分别增加至 78.1% 和 94.1%，表明细胞膜通透性增加。DHAA 的作用相对较弱[1]。
CHIR-29498 (1 小时) 在浓度高于 MIC 时可诱导小鼠 (BALB/c) 或人类红细胞 (RBC) 溶血，但溶血活性较弱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHIR-29498 相关抗体:
体内研究
(In Vivo)

CHIR-29498 (5-30 mg/kg，腹腔注射，一次) 在 CD-1 小鼠中以 10 mg/kg 和 30 mg/kg 的剂量显示出完全保护作用，并且在感染已确立的情况下延迟给药也显示出活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice (weighing approximately 25 grams) were inoculated with approximately 108 CFU of bacteria via intraperitoneal injection[1].
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: I.p., once
Result: Protected 100% of the animals at a dose of 10 mg/kg.
Protected 50% of the animals when dosed (30 mg/kg) 110 min after i.p. infection.
分子量

629.88

Formula

C38H55N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHIR-29498 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIR-29498236102-25-3CHIR29498CHIR 29498BacterialPeptoidsDehydroabietylamineDHAAInhibitorinhibitorinhibit

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产品名称：
CHIR-29498
目录号：
HY-118971
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