2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. CP-31398

CP-31398 可在 p53 突变或野生型的癌细胞中，稳定 p53 的活性构象，促进 p53 的活性。此外，CP-31398 可上调 p53 目标基因，如 p21WAF1/Cip1 和 KILLER/DR5。CP-31398 具有抑制肿瘤生长的作用。

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CP-31398

CP-31398 Chemical Structure

CAS No. : 259199-65-0

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     可免费申领三个不同产品的试用装。

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CP-31398 的其他形式现货产品:

Customer Review

Other Forms of CP-31398:

CP-31398 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
24.78 μM
Compound: CP-31398
Cytotoxicity against human A549 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human A549 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
A549 IC50
> 25 μM
Compound: CP-31398
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human A549 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
DU-145 IC50
15.34 μM
Compound: CP-31398
Cytotoxicity against human DU145 cells expressing mutant type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human DU145 cells expressing mutant type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
HCT-116 IC50
18.63 μM
Compound: CP-31398
Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
HCT-116 IC50
18.63 μM
Compound: CP-31398
Anticancer activity against human HCT116 cells assessed as inhibition of cell proliferation
Anticancer activity against human HCT116 cells assessed as inhibition of cell proliferation
[PMID: 31158748]
HCT-116 IC50
18.63 μM
Compound: CP-31398
Cytotoxicity against human HCT116 cells expressing wild type p53 incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells expressing wild type p53 incubated for 72 hrs by MTS assay
[PMID: 31158748]
HCT-116 IC50
26.28 μM
Compound: CP-31398
Antiproliferative activity against p53-/- human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against p53-/- human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
HCT-116 IC50
26.28 μM
Compound: CP-31398
Cytotoxicity against human HCT116 cells deficient in p53 incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells deficient in p53 incubated for 72 hrs by MTS assay
[PMID: 31158748]
L02 IC50
25.34 μM
Compound: CP-31398
Cytotoxicity against human HL-7702 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human HL-7702 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
MCF7 IC50
26.96 μM
Compound: CP-31398
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
MGC-803 IC50
18.27 μM
Compound: CP-31398
Cytotoxicity against human MGC-803 cells expressing mutant type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human MGC-803 cells expressing mutant type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
NHDF IC50
12.26 μM
Compound: CP-31398
Antiproliferative activity against human NHDF cells after 72 hrs by CellTiter 96 aqueous one solution assay
Antiproliferative activity against human NHDF cells after 72 hrs by CellTiter 96 aqueous one solution assay
[PMID: 30562697]
NHDF IC50
12.26 μM
Compound: CP-31398
Cytotoxicity against human NHDF cells incubated for 72 hrs by MTS assay
Cytotoxicity against human NHDF cells incubated for 72 hrs by MTS assay
[PMID: 31158748]
PANC-1 IC50
> 25 μM
Compound: CP-31398
Cytotoxicity against human PANC1 cells harboring mutant TP53 gene incubated for 72 hrs by MTS assay
Cytotoxicity against human PANC1 cells harboring mutant TP53 gene incubated for 72 hrs by MTS assay
[PMID: 31158748]
PC-3 IC50
16.34 μM
Compound: CP-31398
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
T-24 IC50
20.34 μM
Compound: CP-31398
Cytotoxicity against human T-24 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
Cytotoxicity against human T-24 cells expressing wild type p53 assessed as reduction in cell viability preincubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31761381]
U-251 IC50
18.77 μM
Compound: CP-31398
Cytotoxicity against human U251 cells harboring mutant TP53 gene incubated for 72 hrs by MTS assay
Cytotoxicity against human U251 cells harboring mutant TP53 gene incubated for 72 hrs by MTS assay
[PMID: 31158748]
体外研究
(In Vitro)

CP-31398 (36.75 μM，16 小时) 可在 p53 突变细胞中诱导 p21 的表达[1]。
CP-31398 (15 μg/mL，20 小时) 可在 SW480 细胞中诱导凋亡和细胞周期停滞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP-31398 相关抗体:

Western Blot Analysis[1]

Cell Line: Saos-2 cells expressing transfected mutant p53
Concentration: 36.75 μM
Incubation Time: 16 h
Result: Induction of p21 in cells expressing only mutant p53.

Western Blot Analysis[3]

Cell Line: LN-18 and U87MG cells
Concentration: 36 μM
Incubation Time: 16 h
Result: Decreased the levels of procaspase 3 and induced cleavage of caspase 7.
体内研究
(In Vivo)

CP-31398 (100 mg/kg，口服，每天两次，共 7 天) 在异种移植小鼠模型中表现出显著的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Small human tumor xenografts in mice[1]
Dosage: 100 mg/kg
Administration: Orally twice daily for 7 days
Result: Suppressed A375.S2 tumor growth by -50%.
分子量

362.47

Formula

C22H26N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-31398 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-31398259199-65-0CP31398CP 31398MDM-2/p53ApoptosisSmall human tumor xenograftsSaos-2 cellsLN-18 and U87MG cellsAnti-tumorInhibitorinhibitorinhibit

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