2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. CS-526

CS-526 是一种有效的，竞争性，可逆的和具有口服活性的酸泵 (acid pump) 拮抗剂。CS-526 抑制 H+,K+-ATPase 活性。CS-526 抑制胃酸分泌并预防食道病变。CS-526具有胃食管反流病研究的潜力。

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CS-526 Chemical Structure

CS-526 Chemical Structure

CAS No. : 313272-12-7

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CS-526 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease[1].

体外研究
(In Vitro)

CS-526 (0-100 µM；60 分钟) 抑制 H+ K+-ATP 酶和 Na+ K+ -ATPase 活性呈剂量依赖性，IC50 值分别为 61 nM、10.4 µM[1]。
CS-526 竞争性结合 H+ K+-ATPase 的 K+ 结合位点[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CS-526 相关抗体:
体内研究
(In Vivo)

CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) 以剂量依赖性方式抑制幽门结扎大鼠的胃酸分泌[1]。
CS-526 (1, 3, 10, 30 mg/kg; intrapouch; 180 min) 剂量依赖性地抑制 Heidenhain 袋犬组胺诱导的胃酸分泌[1]。
CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) 可预防食管病变和急性胃粘膜病变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pylorus-Ligated Rats[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: Intraduodenal administration or p.o.
Result: Dose-dependently inhibited gastric acid secretion with ID50 values of 2.8, 0.7 mg/kg for intraduodenal administration and oral administration, respectively.
Animal Model: Reflux Esophagitis Model in Rats[1]
Dosage: 1, 3, 10 mg/kg
Administration: Intraduodenal administration or p.o.
Result: Significantly reduced the lesion scores with ID50 values of 5.4, 1.9 mg/kg for intraduodenal and p.o. respectively.
分子量

339.41

Formula

C20H22FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CS-526 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS-526313272-12-7CS526CS 526Proton Pumpantisecretoryantiulcerorally activegastric acidInhibitorinhibitorinhibit

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