1. Others Metabolic Enzyme/Protease
  2. Oxidative Phosphorylation Mitochondrial Metabolism
  3. Cyanine5 alkyne

Cyanine5 alkyne  (Synonyms: Alkyne-Cy5)

目录号: HY-137042
产品使用指南

Cyanine5 alkyne (Alkyne-Cy5) 是一种荧光染料,用于标记叠氮蛋白,可用于分析蛋白质的翻译后修饰,糖基化等。Cyanine5 alkyne 也可以作为线粒体 OXPHOS 抑制剂,抑制癌症干细胞 (CSC) 的生长。Cyanine5 alkyne 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Cyanine5 alkyne Chemical Structure

Cyanine5 alkyne Chemical Structure

CAS No. : 1223357-57-0

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC)[1][2]. Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

Cyanine5 alkyne (Alkyne-Cy5) (1-1000 nM) significantly inhibits 3D mammosphere formation in MCF7 cells between 500 nM and 1000 nM and can act as a mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, inducing glycolysis to compensate for mitochondrial ATP depletion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

556.18

Formula

C35H42ClN3O

CAS 号
Emission (Em)

670

Excitation (Ex)

645

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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