1. Metabolic Enzyme/Protease
  2. Oxidative Phosphorylation Mitochondrial Metabolism
  3. Cyanine5 alkyne

Cyanine5 alkyne  (Synonyms: Alkyne-Cy5)

目录号: HY-137042 纯度: 98.15%
COA 产品使用指南

Cyanine5 alkyne (Alkyne-Cy5) 是一种荧光染料,用于标记叠氮蛋白,可用于分析蛋白质的翻译后修饰,糖基化等。Cyanine5 alkyne 也可以作为线粒体 OXPHOS 抑制剂,抑制癌症干细胞 (CSC) 的生长。Cyanine5 alkyne 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Cyanine5 alkyne Chemical Structure

Cyanine5 alkyne Chemical Structure

CAS No. : 1223357-57-0

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
5 mg ¥1780
In-stock
10 mg ¥2680
In-stock
25 mg ¥5100
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyanine5 alkyne (Alkyne-Cy5) is a fluorescent dye used to label azide proteins and can be used to analyse post-translational modifications of proteins, glycosylation etc. Cyanine5 alkyne can also be used as a mitochondrial OXPHOS inhibitor to inhibit the growth of cancer stem cells (CSC)[1][2]. Cyanine5 alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

Cyanine5 alkyne (Alkyne-Cy5) (1-1000 nM) significantly inhibits 3D mammosphere formation in MCF7 cells between 500 nM and 1000 nM and can act as a mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, inducing glycolysis to compensate for mitochondrial ATP depletion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

556.18

Formula

C35H42ClN3O

CAS 号
性状

固体

颜色

Brown to black

Emission (Em)

670

Excitation (Ex)

645

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 125 mg/mL (224.75 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7980 mL 8.9899 mL 17.9798 mL
5 mM 0.3596 mL 1.7980 mL 3.5960 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7980 mL 8.9899 mL 17.9798 mL 44.9495 mL
5 mM 0.3596 mL 1.7980 mL 3.5960 mL 8.9899 mL
10 mM 0.1798 mL 0.8990 mL 1.7980 mL 4.4949 mL
15 mM 0.1199 mL 0.5993 mL 1.1987 mL 2.9966 mL
20 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2475 mL
25 mM 0.0719 mL 0.3596 mL 0.7192 mL 1.7980 mL
30 mM 0.0599 mL 0.2997 mL 0.5993 mL 1.4983 mL
40 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1237 mL
50 mM 0.0360 mL 0.1798 mL 0.3596 mL 0.8990 mL
60 mM 0.0300 mL 0.1498 mL 0.2997 mL 0.7492 mL
80 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5619 mL
100 mM 0.0180 mL 0.0899 mL 0.1798 mL 0.4495 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cyanine5 alkyne
目录号:
HY-137042
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