2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. CD47 Reactive Oxygen Species (ROS) Thrombopoietin Receptor
  4. Cys-PKHB1

Cys-PKHB1 (Cys-txCD47) 是一种半胱氨酸（Cys）残基和 PKHB1 偶联的多肽，PKHB1 是一种 CD47 激动剂肽，具有抗肿瘤作用的血栓反应蛋白-1 肽模拟物。PKHB1 在乳腺癌细胞中诱导线粒体改变、ROS 产生、细胞内 Ca+ 积累以及钙依赖性细胞死亡。PKHB1 通过免疫原性细胞死亡乳腺癌细胞诱导免疫系统激活。

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Custom Peptide Synthesis

Cys-PKHB1

Cys-PKHB1 Chemical Structure

CAS No. : 2378833-51-1

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Cys-PKHB1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cys-PKHB1 (Cys-txCD47) is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death[1][2].

分子量

1487.88

Formula

C71H110N18O13S2
CAS 号
Sequence

Cys-{d-Lys}-Arg-Phe-Tyr-Val-Val-Met-Trp-Lys-{d-Lys}
Sequence Shortening

C-{d-Lys}-RFYVVMWK-{d-Lys}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cys-PKHB1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cys-PKHB12378833-51-1Cys-txCD47CD47Reactive Oxygen Species (ROS)Thrombopoietin ReceptorCluster of Differentiation 47MER6OA3peptide mimicantitumor effectsROSbreast cancer cellsInhibitorinhibitorinhibit

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