2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. CZL-S092

CZL-S092 是一种PLK4 抑制剂，对其他 PLK4 家族成员（PLK1、PLK2 和 PLK3）具有极高的选择性，其 IC50 为 0.9 nM。CZL-S092 在体外表现出抗神经母细胞瘤活性 (IMR-32, IC50 = 1.143 μM) ，并且在体内具有良好的口服生物利用度 (SD rats, F =22.1%)。CZL-S092 可用于神经母细胞瘤等多种癌症研究。

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CZL-S092 Chemical Structure

CZL-S092 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CZL-S092 相关抗体

Top Publications Citing Use of Products

查看 Polo-like Kinase (PLK) 亚型特异性产品:

查看所有亚型
PLK1 PLK2 PLK3 PLK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CZL-S092 is a PLK4 inhibitor with an IC50 value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1, PLK2, and PLK3).CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells, IC50 = 1.143 μM) and acceptable oral bioavailability in vivo (SD rats, F = 22.1%). CZL-S092 can be used in studies of various cancers including neuroblastoma cancer[1].

体外研究
(In Vitro)

CZL-S092 (0.5 μM; 60 min) exhibits a significantly increased suppression activity with an IC50 value of 0.9 nM[1].
CZL-S092 (0.5-2.5 μM; 5 d) exhibits the optimal antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively[1].
CZL-S092 (0.5-5 μM; 48 h) induces significant apoptosis (84.3%) in IMR-32 neuroblastoma cells[1].
CZL-S092 (2.5 μM; 48 h) arrestes IMR-32 cells at G2/M phase (87.4%)[1].
CZL-S092 (5.0 μM; 24 h) significantly suppresses IMR-32 cell migration ( > 90%) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CZL-S092 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, IMR-32, SH-SY5Y
Concentration: 0.5 μM, 1.0 μM, 2.5 μM
Incubation Time: 5 days
Result: Exhibited the optimal antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 48 h
Result: Produced a remarkable 87.4% and 89.6% G2/M phase arrest at a concentration of 2.5 μM and 5.0 μM.

Apoptosis Analysis[1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 48 h
Result: Induced the total rate to 84.3% at a concentration of 2.50 μM, and 90.2% at 5.0 μM.

Cell Migration Assay [1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 24 h
Result: Significantly suppressed over 90% of the wound healing with 5.0 μM.

Immunofluorescence[1]

Cell Line: IMR-32
Concentration: 2.5 μM
Incubation Time: 48 h
Result: Occurred disordered centrosome replication and resulted in centriole loss. T.
分子量

418.49

Formula

C23H19FN4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CZL-S092 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CZL-S092Polo-like Kinase (PLK)PLK4 inhibitorsIndazole derivativesNeuroblastomaVirtual screeningFragment-based drug designInhibitorinhibitorinhibit

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产品名称：
CZL-S092
目录号：
HY-176734
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