2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. DAPT

DAPT (GSI-IX) (GMP) 是 GMP 级别的 DAPT (HY-13027)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。DAPT 是一种强效的、具有口服活性的 γ-secretase 抑制剂。

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DAPT

DAPT Chemical Structure

CAS No. : 208255-80-5

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规格 价格 是否有货 数量
10 mg ￥12800
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DAPT 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
34200 nM
Compound: DAPT
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
[PMID: 17932033]
Hep 3B2 IC50
5 μM
Compound: DAPT
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
Huh-7 IC50
5 μM
Compound: DAPT
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
Mahlavu IC50
5 μM
Compound: DAPT
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
SNU-475 IC50
0.6 μM
Compound: DAPT
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
THP-1 IC50
6.3 nM
Compound: DAPT
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
[PMID: 17932033]
THP-1 IC50
> 100000 nM
Compound: DAPT
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
[PMID: 17932033]
体外研究
(In Vitro)

DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts[1].
DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DAPT 相关抗体:
分子量

432.46

Formula

C23H26F2N2O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DAPT 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAPT (GMP)208255-80-5GSI-IX (GMP)γ-secretaseGamma secretaseGMPcell therapy manufacturepotentoralhiPSCmyoblastneuronsInhibitorinhibitorinhibit

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产品名称：
DAPT
目录号：
HY-13027G
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