1. Anti-infection
  2. Dengue virus Flavivirus
  3. DENV-IN-10

DENV-IN-10 是一种有效的四价登革热抑制剂,对 DENV-1-4 血清型的 EC50 分别为 1.36、0.87、0.94 和 0.95 μM。DENV-IN-10 是一种进入后复制抑制剂,似乎对灵长类动物来源的细胞具有特异性。

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DENV-IN-10 Chemical Structure

DENV-IN-10 Chemical Structure

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     可免费申领三个不同产品的试用装。

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC50s of 1.36, 0.87, 0.94, and 0.95 μM against DENV-1-4 serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin[1].

体外研究
(In Vitro)

DENV-IN-10 (10 μM; 在 DENV 感染之前、感染期间或感染后 2, 6, 12, 24 h 添加) 在感染前和感染后没有显着的抗病毒活性,在感染后 2 小时添加降低感染性病毒颗粒的水平,即使在感染后 24 小时添加也仍然有效[1]
DENV-IN-10 (10 μM; 24-60 h) 降低感染 DENV-2 的 Huh-7 细胞中的病毒 RNA 拷贝数和病毒蛋白 NS3 和 NS5 的表达[1]
DENV-IN-10 (0.1-20 μM) 显着抑制 DENV-2 在灵长类动物细胞系中的复制,但在蚊子细胞和幼仓鼠肾细胞中的 EC50 较高[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

475.56

Formula

C26H25N3O4S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

DENV-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DENV-IN-10
目录号:
HY-149251
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